PMID- 33963500
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20211214
IS  - 1572-8595 (Electronic)
IS  - 1383-875X (Linking)
VI  - 62
IP  - 3
DP  - 2021 Dec
TI  - Applicability of the PAINESD risk score for 30-day mortality prediction post 
      ventricular tachycardia catheter ablation in Chagas disease.
PG  - 469-477
LID - 10.1007/s10840-021-00995-z [doi]
AB  - PURPOSE: The PAINESD risk score was developed in 2015 as a tool to stratify the 
      risk of acute hemodynamic decompensation during ventricular tachycardia (VT) 
      ablation in structural heart disease patients and further then used for post 
      procedure 30-day mortality prediction. The original cohort however did not 
      include Chagas disease (ChD) patients. We aim to evaluate the relevance of the 
      score in a ChD population. METHODS: The PAINESD risk score gives weighted values 
      for specific characteristics (chronic obstructive pulmonary disease, age > 60 
      years, ischemic cardiomyopathy, New York Heart Association [NYHA] functional 
      class 3 or 4, ejection fraction less than 25%, VT storm, and diabetes). The score 
      was applied in a retrospective cohort of ChD VT ablations in a single tertiary 
      center in Brazil. Data were collected by VT study reports and patient record 
      analysis at baseline and on follow-up. RESULTS: Between January 2013 and December 
      2018, 157 VT catheter ablation procedures in 121 ChD patients were analyzed. 
      Overall, 30-day mortality was 9.0%. Multivariate analysis correlated NYHA 
      functional class (HR 1.78, 95% CI 1.03-3.08, P 0.038) and the need for urgent 
      surgery (HR 31.5, 95% CI 5.38-184.98, P < 0.001), as well as a tendency for VT 
      storm at presentation (HR 2.72, 95% CI 0.87-8.50, P 0.084) as risk factors for 
      the primary endpoint. The median PAINESD risk score in this population was 3 
      (3-8). The area under the receiver operating characteristic (ROC) curve was 0.64 
      (95% CI 0.479-0.814). CONCLUSIONS: The PAINESD risk score did not perform well in 
      predicting 30-day mortality in ChD patients. Pre-procedure NYHA functional class 
      and the need for urgent surgery due to refractory pericardial bleeding were 
      independently associated with increased 30-day mortality. Prospective studies are 
      needed to take final conclusions in Chagas disease when using PAINESD score.
CI  - (c) 2021. Springer Science+Business Media, LLC, part of Springer Nature.
FAU - Kulchetscki, R M
AU  - Kulchetscki RM
AUID- ORCID: 0000-0002-9322-5641
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Pisani, C F
AU  - Pisani CF
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Alexandre, F K B
AU  - Alexandre FKB
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Mayrink, M P
AU  - Mayrink MP
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Ferraz, A P
AU  - Ferraz AP
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Gouvea, F C
AU  - Gouvea FC
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Goncalves, A L M
AU  - Goncalves ALM
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Hardy, C A
AU  - Hardy CA
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Melo, S L
AU  - Melo SL
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Chokr, M O
AU  - Chokr MO
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil.
FAU - Scanavacca, M I
AU  - Scanavacca MI
AD  - Instituto do Coracao FMUSP, Sao Paulo, Brazil. mauricio.scanavacca@incor.usp.br.
LA  - eng
PT  - Journal Article
DEP - 20210508
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - *Catheter Ablation
MH  - *Chagas Disease
MH  - Humans
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Tachycardia, Ventricular/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - 30-day mortality
OT  - Chagas disease
OT  - PAINESD risk score
OT  - VT ablation
EDAT- 2021/05/09 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/05/08 07:08
PHST- 2021/02/01 00:00 [received]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/05/09 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/08 07:08 [entrez]
AID - 10.1007/s10840-021-00995-z [pii]
AID - 10.1007/s10840-021-00995-z [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2021 Dec;62(3):469-477. doi: 
      10.1007/s10840-021-00995-z. Epub 2021 May 8.