PMID- 33965041
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20210524
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 231
DP  - 2021 Aug 15
TI  - Mapping the distribution of perfluoroalkyl substances in zebrafishes by liquid 
      extraction surface analysis mass spectrometry.
PG  - 122377
LID - S0039-9140(21)00298-8 [pii]
LID - 10.1016/j.talanta.2021.122377 [doi]
AB  - Investigation on the distribution of persistent organic pollutants (POPs) in 
      aquatic organisms is of great importance for exploring the biological toxicity 
      and health risks of environmental pollutants. In this study, a liquid extraction 
      surface analysis mass spectrometry (LESA-MS) method was developed for rapid and 
      in situ analysis of the spatial distribution of perfluoroalkyl substances (PFASs) 
      in zebrafish. By combining the high-precision automated moving platform of LESA 
      device and the high-resolution MS, quantitative analysis of perfluorooctanoic 
      acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in zebrafish tissue section 
      were easily achieved. A tissue-specific ionization efficiency factor (TSF) 
      strategy was also proposed to correct the matrix effect in different parts of 
      zebrafish tissue. By using the developed method, high sensitive and efficient 
      imaging of PFOA and PFOS in zebrafish tissue was achieved, and the distributions 
      of PFOA and PFOS in descending order were gills, organs, roes, pelvic fin, 
      muscle, and brain. The experimental results demonstrated that the coupling of 
      LESA-MS method with TFS strategy is an efficient and reliable approach for 
      monitoring the content distribution of environmental pollutants in biological 
      tissues.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Xiao, Yipo
AU  - Xiao Y
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China.
FAU - Deng, Jiewei
AU  - Deng J
AD  - School of Biomedical and Pharmaceutical Sciences, Guangdong University of 
      Technology, 100 Waihuanxi Road, Guangzhou, 510006, China. Electronic address: 
      jwdeng@126.com.
FAU - Fang, Ling
AU  - Fang L
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China.
FAU - Tu, Lanyin
AU  - Tu L
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China.
FAU - Luan, Tiangang
AU  - Luan T
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China; Institute of 
      Environmental and Ecological Engineering, Guangdong University of Technology, 100 
      Waihuanxi Road, Guangzhou, 510006, China. Electronic address: 
      cesltg@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210406
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - Animals
MH  - Caprylates
MH  - *Environmental Pollutants/analysis
MH  - *Fluorocarbons/analysis
MH  - Tandem Mass Spectrometry
MH  - *Water Pollutants, Chemical
MH  - Zebrafish
OTO - NOTNLM
OT  - Imaging
OT  - Liquid extraction surface analysis
OT  - Mass spectrometry
OT  - Perfluoroalkyl substances
OT  - Tissue-specific ionization efficiency factor
OT  - Zebrafishes
EDAT- 2021/05/10 06:00
MHDA- 2021/05/25 06:00
CRDT- 2021/05/09 20:24
PHST- 2020/12/24 00:00 [received]
PHST- 2021/03/24 00:00 [revised]
PHST- 2021/03/27 00:00 [accepted]
PHST- 2021/05/09 20:24 [entrez]
PHST- 2021/05/10 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
AID - S0039-9140(21)00298-8 [pii]
AID - 10.1016/j.talanta.2021.122377 [doi]
PST - ppublish
SO  - Talanta. 2021 Aug 15;231:122377. doi: 10.1016/j.talanta.2021.122377. Epub 2021 
      Apr 6.