PMID- 33965115
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20210519
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 125
DP  - 2021 Jun
TI  - Ferrocene-functionalized hybrid hydrogel dressing with high-adhesion for 
      combating biofilm.
PG  - 112111
LID - S0928-4931(21)00250-2 [pii]
LID - 10.1016/j.msec.2021.112111 [doi]
AB  - Bacterial infection is a common phenomenon in the process of postoperative wound 
      healing. In severe cases, it may even lead to life-threatening, which brings a 
      heavy burden to the clinical treatment and causes huge losses to the society and 
      economy. As one of the most commonly applied medical materials for wound 
      treatment, hydrogel dressings are mainly used to cover and protect wounds and 
      provide a favorable environment to facilitate wound healing. In this work, we 
      developed an antibacterial hydrogel dressing (Fc-PAAM) with high adhesion, which 
      is consisted of polyacrylamide (PAM) hydrogel framework and polyacrylic 
      acid-functionalized (PAA) with ferrocene (Fc). Morphology, adhesion and pressure 
      resistance of PAAM hydrogel were confirmed by using scanning electron microscope 
      (SEM) and universal testing machine, and Fc decoration in the hydrogel network 
      was well demonstrated by using Fourier transform infrared spectroscopy (FT-IR). 
      Ultraviolet-visible spectroscopy (UV-vis) displayed that the Fc-PAAM hydrogel had 
      excellent peroxidase-like activity as well. It not only exhibited prominent 
      antimicrobial activity against Gram (+/-) bacteria, but also performed high 
      efficiency in preventing the formation of biofilms. In addition, in vivo 
      experiments indicated that this adhesive dressing could significantly prevent 
      bacterial infections. Compared with other clinical treatment methods, this kind 
      of hydrogel is not easy to cause bacterial resistance, and the used raw materials 
      are easy to obtain and low in price, which can amplify the antibacterial 
      properties of H(2)O(2) and provide a new opportunity for the treatment of 
      clinical bacterial infections.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Peng, Yanling
AU  - Peng Y
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China.
FAU - Wang, Zefeng
AU  - Wang Z
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China.
FAU - Wang, Feiying
AU  - Wang F
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China.
FAU - Zhang, Shengnan
AU  - Zhang S
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China.
FAU - He, Dinggeng
AU  - He D
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China; State Key Laboratory of 
      Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 
      410081, Hunan, People's Republic of China. Electronic address: 
      hedinggeng@hnu.edu.cn.
FAU - Deng, Le
AU  - Deng L
AD  - Department of Microbiology, College of Life Science, Hunan Normal University, 
      Changsha 410081, Hunan, People's Republic of China; State Key Laboratory of 
      Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 
      410081, Hunan, People's Republic of China. Electronic address: 
      Dengle@hunnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210418
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydrogels)
RN  - 0 (Metallocenes)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Bandages
MH  - Biofilms
MH  - *Hydrogels
MH  - *Hydrogen Peroxide
MH  - Metallocenes
MH  - Spectroscopy, Fourier Transform Infrared
OTO - NOTNLM
OT  - Adhesive dressing
OT  - Chemodynamic therapy
OT  - Ferrocene
OT  - Hydrogel
OT  - Wound healing
EDAT- 2021/05/10 06:00
MHDA- 2021/05/20 06:00
CRDT- 2021/05/09 20:26
PHST- 2021/01/17 00:00 [received]
PHST- 2021/03/30 00:00 [revised]
PHST- 2021/04/11 00:00 [accepted]
PHST- 2021/05/09 20:26 [entrez]
PHST- 2021/05/10 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
AID - S0928-4931(21)00250-2 [pii]
AID - 10.1016/j.msec.2021.112111 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2021 Jun;125:112111. doi: 
      10.1016/j.msec.2021.112111. Epub 2021 Apr 18.