PMID- 33966442
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20220425
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 38
IP  - 4
DP  - 2021 Jul 29
TI  - Contribution of rs3211938 polymorphism at CD36 to glucose levels, oxidized 
      low-density lipoproteins, insulin resistance, and body mass index in Mexican 
      mestizos with type-2 diabetes from western Mexico.
PG  - 742-748
LID - 10.20960/nh.03447 [doi]
AB  - Background: type-2 diabetes mellitus (T2DM) is a chronic metabolic disorder 
      characterized by hyperglycemia, insulin resistance (IR), and abnormal fatty acid 
      metabolism in which the CD36 receptor has been implicated in glucose and lipid 
      dysregulation. Objective: to evaluate the contribution of polymorphism CD36 
      rs3211938 to metabolic profile in T2DM Mexican mestizos from western Mexico. 
      Methods: we included 115 individuals classified as non-T2DM (NT2DM) adults and 
      T2DM patients. Polymorphism CD36 rs3211938 was assessed by PCR-RFLP. 
      Anthropometric and metabolic markers were measured by routine methods, and 
      insulin and oxidized LDL (ox-LDL) were measured by ELISA. Results: the 
      distribution of genotypes between NT2DM and T2DM patients was different (p < 
      0.001), as was the allele frequency (p = 0.002). NT2DM TG carriers showed the 
      lowest levels of basal insulin and HOMA-IR index in comparison with TT carriers 
      (p < 0.05 and p < 0.05, respectively). In the T2DM group TG carriers showed high 
      BMI, WHR, and weight values (p = 0.001; p </= 0.05 and p < 0.05, respectively), and 
      the highest levels of basal glucose, HDL-cholesterol, ox-LDL, and HOMA-IR (p < 
      0.001; p < 0.001; p < 0.001, and p = 0.001, respectively) in comparison with 
      diabetic TT carriers. Conclusion: the CD36 rs3211938 TG genotype is associated 
      with high levels of glucose, ox-LDL, HDL-cholesterol, and IR, and with increased 
      BMI in Mexican mestizo T2DM patients from western Mexico.
FAU - Martin-Marquez, Beatriz Teresita
AU  - Martin-Marquez BT
AD  - Department of Molecular Biology and Genomics. Instituto de Investigacion en 
      Reumatologia y del Sistema Musculo Esqueletico (IIRSME). Centro Universitario de 
      Ciencias de la Salud. Universidad de Guadalajara.
FAU - Sandoval-Garcia, Flavio
AU  - Sandoval-Garcia F
AD  - Department of Molecular Biology and Genomics. Instituto de Investigacion en 
      Reumatologia y del Sistema Musculo Esqueletico (IIRSME). Centro Universitario de 
      Ciencias de la Salud. Universidad de Guadalajara.
FAU - Vazquez-Del Mercado, Monica
AU  - Vazquez-Del Mercado M
AD  - Department of Molecular Biology and Genomics. Instituto de Investigacion en 
      Reumatologia y del Sistema Musculo Esqueletico (IIRSME). Centro Universitario de 
      Ciencias de la Salud. Universidad de Guadalajara.
FAU - Martinez-Garcia, Erika-Aurora
AU  - Martinez-Garcia EA
AD  - Department of Molecular Biology and Genomics. Instituto de Investigacion en 
      Reumatologia y del Sistema Musculo Esqueletico (IIRSME). Centro Universitario de 
      Ciencias de la Salud. Universidad de Guadalajara.
FAU - Corona-Meraz, Fernanda-Isadora
AU  - Corona-Meraz FI
AD  - CA-701, Ageing, Immuno-Metabolism, and Oxidative Stress. Department of Public 
      Health. Universidad de Guadalajara.
FAU - Fletes-Rayas, Ana-Lilia
AU  - Fletes-Rayas AL
AD  - Department of Applied Integral Clinical Nursing. Centro Universitario de Ciencias 
      de la Salud. Universidad de Guadalajara. Guadalajara.
FAU - Zavaleta-Muniz, Soraya-Amali
AU  - Zavaleta-Muniz SA
AD  - Facultad de Ciencias de la Salud. Universidad Juarez del Estado de Durango.
LA  - eng
PT  - Journal Article
TT  - Contribucion del polimorfismo rs3211938 de CD36 a los niveles de glucosa, las 
      lipoproteinas de baja densidad oxidadas, la resistencia a la insulina y el indice 
      de masa corporal en mestizos mexicanos con diabetes de tipo 2 del occidente de 
      Mexico.
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
RN  - 0 (CD36 Antigens)
RN  - 0 (CD36 protein, human)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - CD36 Antigens/*genetics/metabolism
MH  - Diabetes Mellitus, Type 2/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Insulin Resistance/genetics/physiology
MH  - Lipoproteins, LDL/analysis/metabolism
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
OTO - NOTNLM
OT  - Diabetes de tipo 2. CD36. Glucosa. Resistencia a la insulina. LDL-ox. IMC.
EDAT- 2021/05/11 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/05/10 05:29
PHST- 2021/05/11 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/10 05:29 [entrez]
AID - 10.20960/nh.03447 [doi]
PST - ppublish
SO  - Nutr Hosp. 2021 Jul 29;38(4):742-748. doi: 10.20960/nh.03447.