PMID- 3396677
OWN - NLM
STAT- MEDLINE
DCOM- 19880901
LR  - 20131121
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 1
IP  - 4
DP  - 1988 Apr
TI  - Metabolic enzymatic activities in the intercostal and serratus muscles and in the 
      latissimus dorsi of middle-aged normal men and patients with moderate obstructive 
      pulmonary disease.
PG  - 376-83
AB  - The glycolytic and oxidative enzyme activities (lactate dehydrogenase (LDH), 
      hexokinase (HK), citrate synthase (CS) and 3-hydroxyacyl-CoA-dehydrogenase (HAD] 
      were measured in the fifth internal and external intercostal muscles, in the 
      vertical and horizontal parts of the serratus, an accessory inspiratory muscle, 
      and in a non-respiratory muscle, the latissimus dorsi (LD) of twenty middle-aged 
      men: nine subjects with normal lung function and eleven patients with moderate 
      chronic obstructive pulmonary disease (COPD). In the normal subjects the enzyme 
      activities of the respiratory muscles were similar to those of the LD, and there 
      were no differences between the internal and the external intercostal muscles. In 
      the COPD patients the metabolic activities of HK, CS and HAD were higher in both 
      intercostals than in LD. Furthermore, there was a significant increase in these 
      enzymatic activities as compared to the intercostals of the normal subjects. 
      These data support the hypothesis that the internal and external intercostal 
      muscles play a more important role in COPD patients than in normal subjects. They 
      are consistent with the hypothesis that COPD has an endurance training effect on 
      both intercostal muscles which could compensate for diaphragmatic disuse.
FAU - Sanchez, J
AU  - Sanchez J
AD  - Laboratoire de Physiologie du Travail-C.N.R.S. (UA 385), Paris.
FAU - Brunet, A
AU  - Brunet A
FAU - Medrano, G
AU  - Medrano G
FAU - Debesse, B
AU  - Debesse B
FAU - Derenne, J P
AU  - Derenne JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 4.1.3.- (Oxo-Acid-Lyases)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/*metabolism
MH  - Citrate (si)-Synthase/*metabolism
MH  - Hexokinase/*metabolism
MH  - Humans
MH  - Intercostal Muscles/*enzymology
MH  - L-Lactate Dehydrogenase/*metabolism
MH  - Lung Diseases, Obstructive/*enzymology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction
MH  - Muscles/*enzymology
MH  - Oxo-Acid-Lyases/*metabolism
MH  - Respiratory Muscles/enzymology
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1988 Apr;1(4):376-83.