PMID- 33967088
OWN - NLM
STAT- MEDLINE
DCOM- 20210511
LR  - 20240321
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 46
IP  - 4
DP  - 2021 Apr 28
TI  - Progress in study on the association between HLA genetic variation and adverse 
      drug reactions.
PG  - 404-413
LID - 1672-7347(2021)04-0404-10 [pii]
LID - 10.11817/j.issn.1672-7347.2021.200256 [doi]
AB  - The human leukocyte antigen (HLA) molecules encoded within the human major 
      histocompatibility complex are a group of highly conserved cell surface proteins, 
      which are related to antigen recognition. HLA genes display a high degree of 
      genetic polymorphism, which is the basis of individual differences in immunity. 
      Specific HLA genotypes have been highly associated with typical adverse drug 
      reactions. HLA-A*31:01 and HLA-B*15:02 are associated with carbamazepine-induced 
      severe cutaneous adverse reactions, HLA-B*57:01 is related to abacavir-induced 
      drug-induced hypersensitivity syndrome and flucloxacillin/pazopanib-induced 
      drug-induced liver injury, while HLA-B*35:01 is a potential biomarker for 
      predicting polygonum multiflorum-induced liver injury. It is not clear how small 
      drug molecules to interact with HLA molecules and T cell receptors (TCR). There 
      are four mechanistic hypotheses, including the hapten/prohapten theory, the 
      pharmacological interaction concept, the altered peptide repertoire model, and 
      the altered TCR repertoire model.
FAU - Liu, Yating
AU  - Liu Y
AD  - Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 
      Changsha 410008. 188111105@csu.edu.cn.
AD  - Institute of Clinical Pharmacology, Central South University; Hunan Key 
      Laboratory of Pharmacogenetics, Changsha 410078. 188111105@csu.edu.cn.
FAU - Zeng, Xiangchang
AU  - Zeng X
AD  - Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 
      Changsha 410008.
AD  - Institute of Clinical Pharmacology, Central South University; Hunan Key 
      Laboratory of Pharmacogenetics, Changsha 410078.
FAU - Ouyang, Dongsheng
AU  - Ouyang D
AD  - Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 
      Changsha 410008. 801940@csu.edu.cn.
AD  - Institute of Clinical Pharmacology, Central South University; Hunan Key 
      Laboratory of Pharmacogenetics, Changsha 410078. 801940@csu.edu.cn.
AD  - Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha 410205, 
      China. 801940@csu.edu.cn.
LA  - eng
LA  - chi
GR  - 2017ZX09304014/the National Development of Key Novel Drugs for Special Projects/
GR  - 2019SK2241/the Key Research and Development Programs of Hunan Province/
GR  - 2019GK5020/the Innovation and Entrepreneurship Investment Project in Hunan 
      Province/
GR  - 2019CB1014/the International Scientific and Technological Innovation Cooperation 
      Base for Bioanalysis of Complex Matrix Samples in Hunan Province/
PT  - Journal Article
TT  - 人类白细胞抗原基因的遗传变异与药物不良反应的关系.
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Drug-Related Side Effects and Adverse Reactions/genetics
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Polymorphism, Genetic
PMC - PMC10930308
OAB - The human leukocyte antigen (HLA) molecules encoded within the human major 
      histocompatibility complex are a group of highly conserved cell surface proteins, 
      which are related to antigen recognition. HLA genes display a high degree of 
      genetic polymorphism, which is the basis of individual differences in immunity. 
      Specific HLA genotypes have been highly associated with typical adverse drug 
      reactions. HLA-A*31:01 and HLA-B*15:02 are associated with carbamazepine-induced 
      severe cutaneous adverse reactions, HLA-B*57:01 is related to abacavir-induced 
      drug-induced hypersensitivity syndrome and flucloxacillin/pazopanib-induced 
      drug-induced liver injury, while HLA-B*35:01 is a potential biomarker for 
      predicting polygonum multiflorum-induced liver injury. It is not clear how small 
      drug molecules to interact with HLA molecules and T cell receptors (TCR). There 
      are four mechanistic hypotheses, including the hapten/prohapten theory, the 
      pharmacological interaction concept, the altered peptide repertoire model, and 
      the altered TCR repertoire model.
OABL- eng
OTO - NOTNLM
OT  - adverse drug reaction
OT  - genetic polymorphism
OT  - human leukocyte antigen
OT  - immunity
COIS- 作者声称无任何利益冲突。
EDAT- 2021/05/11 06:00
MHDA- 2021/05/12 06:00
PMCR- 2021/04/28
CRDT- 2021/05/10 06:11
PHST- 2021/05/10 06:11 [entrez]
PHST- 2021/05/11 06:00 [pubmed]
PHST- 2021/05/12 06:00 [medline]
PHST- 2021/04/28 00:00 [pmc-release]
AID - 1672-7347(2021)04-0404-10 [pii]
AID - 10.11817/j.issn.1672-7347.2021.200256 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Apr 28;46(4):404-413. doi: 
      10.11817/j.issn.1672-7347.2021.200256.