PMID- 3396795
OWN - NLM
STAT- MEDLINE
DCOM- 19880908
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 10
IP  - 4
DP  - 1988 May
TI  - An immunotoxicological evaluation of 4,4'-thiobis-(6-t-butyl-m-cresol) in female 
      B6C3F1 mice. 1. Body and organ weights, hematology, serum chemistries, bone 
      marrow cellularity, and hepatic microsomal parameters.
PG  - 691-700
AB  - Adult female B6C3F1 mice were gavaged with 4,4'-thiobis-(6-t-butyl-m-cresol) 
      (TBBC) in corn oil at doses of 10, 100, or 200 mg/kg daily for 14 consecutive 
      days. There was no overt toxicity, as manifested by grossly observable behavioral 
      changes, decreased growth rate over the exposure period, or mortality. There were 
      also no marked effects on serum chemistries or hematology, with the exception of 
      a significant increase (41%) in the number of leukocytes at the highest dose. 
      Absolute differential counts indicated that significant increases occurred in the 
      number of lymphocytes (31%) and neutrophils (177%). Studies with bone marrow 
      indicated a significant 30% increase in the number of cells/femur from animals 
      treated with the highest dose of TBBC. The number of macrophage progenitors 
      (CFU-M)/femur was significantly increased by 28%, while the number of 
      granulocyte-monocyte progenitors (CFU-GM)/femur was nonsignificantly increased by 
      20% in the high dose animals. The weight of both the spleen and liver was 
      increased in a dose-related fashion, although the histopathology of the spleen of 
      TBBC-treated mice was not different from control. The livers of mice receiving 
      the high dose showed mild focal hydropic degeneration, mild hepatitis, and a 
      slight increase in the number of Kupffer cells. No other organs were affected. 
      Liver microsomal protein and cytochrome P-450 levels were increased in a 
      dose-related fashion. Enzyme activities of aminopyrine demethylase and aniline 
      hydroxylase, but not arylhydrocarbon hydroxylase, were also increased in a 
      dose-related fashion.
FAU - Munson, A E
AU  - Munson AE
AD  - Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia 
      Commonwealth University, Richmond 23298.
FAU - White, K L Jr
AU  - White KL Jr
FAU - Barnes, D W
AU  - Barnes DW
FAU - Musgrove, D L
AU  - Musgrove DL
FAU - Lysy, H H
AU  - Lysy HH
FAU - Holsapple, M P
AU  - Holsapple MP
LA  - eng
GR  - ES-1-5001/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Cresols)
RN  - 96-69-5 (4,4'-thiobis(6-tert-butyl-3-cresol))
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Blood Chemical Analysis
MH  - Body Weight/drug effects
MH  - Bone Marrow/pathology
MH  - Bone Marrow Cells
MH  - Cresols/*toxicity
MH  - Female
MH  - Glutathione/metabolism
MH  - Immunity/*drug effects
MH  - Leukocyte Count
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Microsomes, Liver/drug effects/metabolism
MH  - Organ Size/drug effects
EDAT- 1988/05/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1988/05/01 00:00
PHST- 1988/05/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1988/05/01 00:00 [entrez]
AID - 10.1016/0272-0590(88)90196-0 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1988 May;10(4):691-700. doi: 10.1016/0272-0590(88)90196-0.