PMID- 33968141
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210513
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 12
DP  - 2021
TI  - A Novel Signature for Predicting Prognosis of Smoking-Related Squamous Cell 
      Carcinoma.
PG  - 666371
LID - 10.3389/fgene.2021.666371 [doi]
LID - 666371
AB  - Tobacco smoking is an established risk factor for squamous cell carcinoma (SCC). 
      We obtained smoking-related SCC, including cervical SCC (CSCC), esophageal SCC 
      (ESCC), head and neck SCC (HNSC), and lung SCC (LUSC), from The Cancer Genome 
      Atlas (TCGA) database to investigate the association between smoking status 
      (reformed and current smoking) and prognosis. We found that reformed smokers had 
      a better prognosis than current smokers in CSCC (p = 0.003), HNSC (p = 0.019), 
      and LUSC (p < 0.01) cohorts. Then, we selected LUSC cohorts as the training 
      cohort and other SCC cohorts as the test cohorts. Function analysis revealed that 
      homologous recombination (HR) was the most significant pathway involved in 
      smoking-induced LUSC. Moreover, the effect of cross-talk between the smoking 
      status and HR deficiency (HRD) on the prognosis was further evaluated, revealing 
      that quitting smoking with high HRD scores could significantly improve patients' 
      prognosis (p < 0.01). To improve prognosis prediction and more effectively screen 
      suitable populations for platinum drugs and poly-ADP-ribose polymerase (PARP) 
      inhibitors, we constructed a risk score model using smoking- and HRD-related 
      genes in LUSC. The risk score model had high power for predicting 2-, 3-, and 
      5-year survival (p < 0.01, AUC = 0.67, 0.66, and 0.66). In addition, the risk 
      scores were an independent risk factor for LUSC (HR = 2.34, 95%CI = 1.70-3.23). 
      The practical nomogram was also built using the risk score, smoking status, and 
      other clinical information with a good c-index (0.72, 95%CI = 0.70-0.74). 
      Finally, we used other TCGA SCC cohorts to confirm the reliability and validity 
      of the risk score model (p < 0.01 and AUC > 0.6 at 2, 3, and 5 years in CSCC and 
      HNSC cohorts). In conclusion, the present study suggested that smoking cessation 
      should be a part of smoking-related SCC treatment, and also provided a risk score 
      model to predict prognosis and improve the effectiveness of screening the 
      platinum/PARP population.
CI  - Copyright (c) 2021 Chen, Cheng, Li, Chen, Cui, Bian and Jin.
FAU - Chen, Chang
AU  - Chen C
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Cheng, Xiaoqing
AU  - Cheng X
AD  - Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Institution 
      of Public Health), Nanjing, China.
FAU - Li, Shuyan
AU  - Li S
AD  - Anhui Province Veterans Hospital, Bengbu, China.
FAU - Chen, Huanghui
AU  - Chen H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Cui, Mengjing
AU  - Cui M
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Bian, Linlin
AU  - Bian L
AD  - Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Institution 
      of Public Health), Nanjing, China.
FAU - Jin, Hui
AU  - Jin H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Southeast University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20210422
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC8100348
OTO - NOTNLM
OT  - SCC
OT  - homologous recombination deficiency
OT  - prognosis
OT  - risk score model
OT  - smoking cessation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/11 06:00
MHDA- 2021/05/11 06:01
PMCR- 2021/04/22
CRDT- 2021/05/10 06:22
PHST- 2021/02/10 00:00 [received]
PHST- 2021/03/23 00:00 [accepted]
PHST- 2021/05/10 06:22 [entrez]
PHST- 2021/05/11 06:00 [pubmed]
PHST- 2021/05/11 06:01 [medline]
PHST- 2021/04/22 00:00 [pmc-release]
AID - 10.3389/fgene.2021.666371 [doi]
PST - epublish
SO  - Front Genet. 2021 Apr 22;12:666371. doi: 10.3389/fgene.2021.666371. eCollection 
      2021.