PMID- 33971329
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20220531
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 34
DP  - 2021 Jun
TI  - Comparison of ganglion cell-inner plexiform layer thickness in exfoliative 
      glaucoma and primary open-angle glaucoma.
PG  - 102335
LID - S1572-1000(21)00161-7 [pii]
LID - 10.1016/j.pdpdt.2021.102335 [doi]
AB  - PURPOSE: To determine and compare the thickness of the ganglion cell-inner 
      plexiform layer (GCIPL), the thickness of the retina nerve fiber layer (RNFL), 
      and the parameters of the optic nerve head (ONH) in exfoliative glaucoma (XFG), 
      primary open-angle glaucoma (POAG), and control eyes using optical coherence 
      tomography (OCT). METHODS: The study was a retrospective observational 
      cross-sectional study of 43 eyes of patients with XFG, 44 eyes of patients with 
      POAG, and 37 eyes of healthy participants. Visual acuity, intraocular pressure, 
      central corneal thickness, rim-area, disc-area, average cup/disc ratio, vertical 
      cup/disc ratio, cup volume, average RNFL thickness, and GCIPL (average, minimum, 
      superior, superotemporal, superonasal, inferior, inferotemporal, and inferonasal) 
      thicknesses were determined. RESULTS: RNFL thicknesses were similar in the XFG 
      and POAG groups (p = 0.065), and both glaucoma groups had significantly thinner 
      RNFLs than the controls (p = 0.002). The XFG group had significantly thinner 
      average and minimum GCIPLs compared to the POAG and control groups (p = 0.027, p 
      < 0.001 for average thickness and p = 0.038, p < 0.001 for minimum thickness, 
      respectively). No significant difference was found in the ONH parameters among 
      the three groups except for rim-area and cup volume (p > 0.05 for all ONH 
      parameters, p < 0.001 for rim-area, and p = 0.003 for cup volume). Mean visual 
      field mean deviation was -11.6 +/- 8.2 dB in the XFG group and -10.4 +/- 9.3 dB in 
      the POAG group (p = 0.453). CONCLUSION: Eyes with XFG were found to have a 
      thinner GCIPL (minimum and average) than eyes with POAG or from healthy controls, 
      although the RNFL measurements were similar to those of eyes with POAG. GCIPL 
      thickness may be a more valuable indicator than RNFL thickness in patients with 
      XFG for early detection of glaucoma and/or for glaucoma progression measurement. 
      There is still some debate in the literature about whether decreases in GCIPL 
      thickness and RNFL thickness (and/or ONH parameter change) are the best 
      indicators for early detection and progress measurement of glaucoma.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Demirtas, Atilim Armagan
AU  - Demirtas AA
AD  - Department of Ophthalmology, Health Sciences University, Tepecik Training and 
      Research Hospital, Izmir, Turkey; Department of OphthalmOlogy, Health Sciences 
      University, Kayseri Training and Research Hospital, Kayseri, Turkey. Electronic 
      address: atilimdemirtas77@gmail.com.
FAU - Ozkose Cicek, Ayse
AU  - Ozkose Cicek A
AD  - Department of OphthalmOlogy, Health Sciences University, Kayseri Training and 
      Research Hospital, Kayseri, Turkey.
FAU - Duru, Zeynep
AU  - Duru Z
AD  - Department of OphthalmOlogy, Health Sciences University, Kayseri Training and 
      Research Hospital, Kayseri, Turkey.
FAU - Ulusoy, Dondu Melek
AU  - Ulusoy DM
AD  - Department of OphthalmOlogy, Health Sciences University, Kayseri Training and 
      Research Hospital, Kayseri, Turkey.
FAU - Ozsaygili, Cemal
AU  - Ozsaygili C
AD  - Department of OphthalmOlogy, Health Sciences University, Kayseri Training and 
      Research Hospital, Kayseri, Turkey.
FAU - Duru, Necati
AU  - Duru N
AD  - Department of OphthalmOlogy, Health Sciences University, Kayseri Training and 
      Research Hospital, Kayseri, Turkey.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210508
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Glaucoma
MH  - *Glaucoma, Open-Angle/diagnosis
MH  - Humans
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents
MH  - Retina
MH  - Retinal Ganglion Cells
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Exfoliative glaucoma
OT  - Ganglion cell-inner plexiform layer thickness
OT  - Optical coherence tomography
OT  - Primary open-angle glaucoma
OT  - Retina nerve fiber layer thickness
EDAT- 2021/05/11 06:00
MHDA- 2021/07/01 06:00
CRDT- 2021/05/10 20:15
PHST- 2021/02/07 00:00 [received]
PHST- 2021/04/23 00:00 [revised]
PHST- 2021/05/03 00:00 [accepted]
PHST- 2021/05/11 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/05/10 20:15 [entrez]
AID - S1572-1000(21)00161-7 [pii]
AID - 10.1016/j.pdpdt.2021.102335 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2021 Jun;34:102335. doi: 
      10.1016/j.pdpdt.2021.102335. Epub 2021 May 8.