PMID- 33971358
OWN - NLM
STAT- MEDLINE
DCOM- 20211029
LR  - 20221003
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 127
IP  - 4
DP  - 2021 Oct
TI  - Increased risk of asthma at age 10 years for children sensitized to multiple 
      allergens.
PG  - 441-445.e1
LID - S1081-1206(21)00336-7 [pii]
LID - 10.1016/j.anai.2021.04.028 [doi]
AB  - BACKGROUND: Childhood sensitization patterns have been previously found to be 
      related to variable risk of early life allergic disease in several birth cohorts. 
      OBJECTIVE: To determine whether these risks persist into later childhood. 
      METHODS: In the birth cohort of the Wayne County Health, Environment, Allergy and 
      Asthma Longitudinal Study, previous latent class analysis based on sensitization 
      to 10 allergens found the following 4 early life sensitization patterns at age 2 
      years: "highly sensitized," "milk/egg dominated," "peanut and inhalant(s)," and 
      "low to no sensitization." At an age 10 study-specific visit, children were 
      evaluated by an allergist for current asthma and atopic dermatitis through a 
      physical examination and interviews with the child and parent or guardian. Total 
      and specific immunoglobulin E (IgE), spirometry, and methacholine challenge were 
      also completed. RESULTS: Compared with children sensitized to none or 1 allergen, 
      children sensitized to 4 or more food and inhalant allergens at age 2 had the 
      highest risk of current asthma (relative risk [RR], 4.42; 95% confidence interval 
      [CI], 2.58-7.59; P < .001) and bronchial hyperresponsiveness (RR, 1.77; 95% CI, 
      1.29-2.42; P < .001). In addition, they had the highest levels of total IgE 
      (geometric mean, 800 IU/mL; 95% CI, 416-1536) among the 4 groups. Risk of current 
      atopic dermatitis did not depend on pattern of sensitization but remained 
      increased for children with any sensitization (RR, 2.23; 95% CI, 1.40-3.55; P < 
      .001). No differences in spirometry (forced expiratory volume in 1 second, forced 
      expiratory flow between 25% and 75%, and forced expiratory volume in 1 
      second/forced vital capacity) were identified. CONCLUSION: The previously 
      reported importance of a specific pattern of sensitization in early life 
      (sensitization to >/=4 inhalant and food allergens) continues to be associated with 
      an increased risk of asthma, bronchial hyperresponsiveness, and high total IgE at 
      age 10 years.
CI  - Copyright (c) 2021 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Havstad, Suzanne L
AU  - Havstad SL
AD  - Department of Public Health Sciences, Henry Ford Health System, Detroit, 
      Michigan. Electronic address: Shavsta1@hfhs.org.
FAU - Sitarik, Alexandra
AU  - Sitarik A
AD  - Department of Public Health Sciences, Henry Ford Health System, Detroit, 
      Michigan.
FAU - Kim, Haejin
AU  - Kim H
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, Henry Ford 
      Health System, Detroit, Michigan.
FAU - Zoratti, Edward M
AU  - Zoratti EM
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, Henry Ford 
      Health System, Detroit, Michigan.
FAU - Ownby, Dennis
AU  - Ownby D
AD  - Department of Pediatrics, Medical College of Georgia, Augusta University, 
      Augusta, Georgia.
FAU - Johnson, Christine Cole
AU  - Johnson CC
AD  - Department of Public Health Sciences, Henry Ford Health System, Detroit, 
      Michigan.
FAU - Wegienka, Ganesa
AU  - Wegienka G
AD  - Department of Public Health Sciences, Henry Ford Health System, Detroit, 
      Michigan.
LA  - eng
GR  - R56 AI050681/AI/NIAID NIH HHS/United States
GR  - R01 AI110450/AI/NIAID NIH HHS/United States
GR  - R01 HL113010/HL/NHLBI NIH HHS/United States
GR  - P01 AI089473/AI/NIAID NIH HHS/United States
GR  - R01 AI050681/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210508
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Asthma/diagnosis/*epidemiology
MH  - Bronchial Hyperreactivity/diagnosis/*immunology
MH  - Child
MH  - Egg Hypersensitivity/immunology
MH  - Female
MH  - Food Hypersensitivity/*epidemiology/immunology
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Milk Hypersensitivity
MH  - Peanut Hypersensitivity/immunology
MH  - Spirometry
MH  - Vital Capacity/physiology
MH  - Young Adult
PMC - PMC8487903
MID - NIHMS1702109
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/05/11 06:00
MHDA- 2021/10/30 06:00
PMCR- 2022/10/01
CRDT- 2021/05/10 20:15
PHST- 2020/12/17 00:00 [received]
PHST- 2021/04/27 00:00 [revised]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/05/11 06:00 [pubmed]
PHST- 2021/10/30 06:00 [medline]
PHST- 2021/05/10 20:15 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - S1081-1206(21)00336-7 [pii]
AID - 10.1016/j.anai.2021.04.028 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2021 Oct;127(4):441-445.e1. doi: 
      10.1016/j.anai.2021.04.028. Epub 2021 May 8.