PMID- 33971459 OWN - NLM STAT- MEDLINE DCOM- 20210811 LR - 20210811 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 155 DP - 2021 Oct TI - Associations of accumulated selected persistent organic pollutants in adipose tissue with insulin sensitivity and risk of incident type-2 diabetes. PG - 106607 LID - S0160-4120(21)00232-4 [pii] LID - 10.1016/j.envint.2021.106607 [doi] AB - Continuous exposure to low doses of persistent organic pollutant (POPs), such as those occurring in the general population, might contribute to the burden of type 2 diabetes mellitus (T2DM). However, evidences from longitudinal studies are scarce. We aimed to explore the associations of accumulated POP exposure with the development of T2DM by means of 1) longitudinal associations with the 16-year incidence of the disease, and 2) complementary cross-sectional analyses with markers of glucose homeostasis at recruitment. Organochlorine pesticide and polychlorinated biphenyl (PCB) concentrations were analyzed in adipose tissue samples and incident T2DM cases were retrieved from clinical records. Homeostatic model assessment values of insulin sensitivity/resistance and beta-cell function at recruitment were calculated. Linear and Cox-regression models were performed. In individuals with normal weight/overweight (n = 293), we observed positive dose-response relationships between the studied POPs and T2DM risk, particularly for hexachlorobenzene (HCB) [hazard ratio (HR): 3.96 for 4th quartile versus 1st quartile (Q1); confidence interval (CI) 95%: 0.79, 19.71]. PCB-180 showed a positive but seemingly non-linear association with T2DM risk [HR of 3(er) quartile (Q3) versus Q1: 6.48; CI 95%: 0.82, 51.29]. Unadjustment for body mass index considerably increased the magnitude of the associations. In the cross-sectional study (n = 180), HCB and PCB-180 were inversely associated with insulin sensitivity and positively associated with insulin resistance parameters. Our results suggest that a higher burden of specific POPs in adipose tissue may disrupt glucose homeostasis, possibly contributing to increase T2DM risk, especially in non-obese adults. CI - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Barrios-Rodriguez, Rocio AU - Barrios-Rodriguez R AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: rbarrios@ugr.es. FAU - Perez-Carrascosa, Francisco M AU - Perez-Carrascosa FM AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Servicio de Oncologia Radioterapica. Hospital Universitario Virgen de las Nieves, Granada, Spain. Electronic address: fperezcar@gmail.com. FAU - Gomez-Pena, Celia AU - Gomez-Pena C AD - Department of Pharmacy, San Cecilio University Hospital, Granada, Spain. Electronic address: celiagp1987@gmail.com. FAU - Mustieles, Vicente AU - Mustieles V AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; University of Granada, Center for Biomedical Research (CIBM), Spain. Electronic address: vmustieles@ugr.es. FAU - Salcedo-Bellido, Inmaculada AU - Salcedo-Bellido I AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: isalcedo@ugr.es. FAU - Requena, Pilar AU - Requena P AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain. Electronic address: prequena@ugr.es. FAU - Martin-Olmedo, Piedad AU - Martin-Olmedo P AD - Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Andalusian School of Public Health (EASP), Granada, Spain. Electronic address: piedad.martin.easp@juntadeandalucia.es. FAU - Jimenez-Moleon, Jose Juan AU - Jimenez-Moleon JJ AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: jjmoleon@ugr.es. FAU - Arrebola, Juan Pedro AU - Arrebola JP AD - Universidad de Granada. Departamento de Medicina Preventiva y Salud Publica, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: jparrebola@ugr.es. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210507 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) SB - IM MH - Adipose Tissue MH - Adult MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/epidemiology MH - *Environmental Pollutants/toxicity MH - Humans MH - *Insulin Resistance MH - Persistent Organic Pollutants OTO - NOTNLM OT - Adipose tissue OT - Glucose homeostasis OT - HOMA OT - Persistent organic pollutants OT - Type 2 diabetes mellitus EDAT- 2021/05/11 06:00 MHDA- 2021/08/12 06:00 CRDT- 2021/05/10 20:19 PHST- 2021/01/22 00:00 [received] PHST- 2021/04/23 00:00 [revised] PHST- 2021/04/26 00:00 [accepted] PHST- 2021/05/11 06:00 [pubmed] PHST- 2021/08/12 06:00 [medline] PHST- 2021/05/10 20:19 [entrez] AID - S0160-4120(21)00232-4 [pii] AID - 10.1016/j.envint.2021.106607 [doi] PST - ppublish SO - Environ Int. 2021 Oct;155:106607. doi: 10.1016/j.envint.2021.106607. Epub 2021 May 7.