PMID- 33971544
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20211214
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 223
DP  - 2021 Jul
TI  - Role and mechanism of action of circular RNA and laryngeal cancer.
PG  - 153460
LID - S0344-0338(21)00121-7 [pii]
LID - 10.1016/j.prp.2021.153460 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC), is the second most common malignant 
      cancer of the head and neck after oral cavity cancer. Laryngeal cancer is 
      associated with huge socio-economic burden worldwide. Studies have widely 
      explored the role of non-coding RNAs, especially microRNAs and long non-coding 
      RNAs in pathogenesis of laryngeal cancer. In addition, several studies have 
      explored the mechanism and function of circRNAs. CircRNAs has higher stability 
      and more extensive function models, including combining miRNA as sponge, 
      modifying transcription, and even regulating protein translation have been 
      developed. Therefore, circRNAs is applied as an excellent diagnostic tool and a 
      promising candidate for development of cancer therapies. This study reviews the 
      biogenesis and function of circRNAs, explores potential mechanism of circRNAs in 
      LSCC, and implications and challenges in LSCC research.
CI  - Copyright (c) 2021 Elsevier GmbH. All rights reserved.
FAU - Wu, Shanying
AU  - Wu S
AD  - Department of Otolaryngology, Linyi Central Hospital, Linyi, 276400 Shandong, 
      China.
FAU - Huang, Xiaodong
AU  - Huang X
AD  - Department of Otolaryngology, Linyi Central Hospital, Linyi, 276400 Shandong, 
      China.
FAU - Tie, Xinting
AU  - Tie X
AD  - Department of Otolaryngology, Linyi Central Hospital, Linyi, 276400 Shandong, 
      China.
FAU - Cheng, Yongshan
AU  - Cheng Y
AD  - Department of Otolaryngology, Linyi Central Hospital, Linyi, 276400 Shandong, 
      China.
FAU - Xue, Xue
AU  - Xue X
AD  - Department of Otolaryngology, Linyi Central Hospital, Linyi, 276400 Shandong, 
      China.
FAU - Fan, Mingfang
AU  - Fan M
AD  - Clinical Laboratory, Linyi Central Hospital, Linyi, 276400 Shandong, China. 
      Electronic address: fan_mingfang@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210430
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - MicroRNAs/genetics/metabolism
MH  - RNA, Circular/genetics/*metabolism
MH  - Signal Transduction
MH  - Squamous Cell Carcinoma of Head and Neck/genetics/*metabolism/pathology
MH  - Transcription, Genetic
OTO - NOTNLM
OT  - Biomarker
OT  - LSCC
OT  - Laryngeal cancer
OT  - ciRNA
OT  - circRNA
EDAT- 2021/05/11 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/05/10 20:25
PHST- 2021/01/28 00:00 [received]
PHST- 2021/04/27 00:00 [revised]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/05/11 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/10 20:25 [entrez]
AID - S0344-0338(21)00121-7 [pii]
AID - 10.1016/j.prp.2021.153460 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2021 Jul;223:153460. doi: 10.1016/j.prp.2021.153460. Epub 2021 
      Apr 30.