PMID- 33972012
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1976-670X (Electronic)
IS  - 1976-6696 (Print)
IS  - 1976-6696 (Linking)
VI  - 54
IP  - 5
DP  - 2021 May
TI  - Advances in higher-order chromatin architecture: the move towards 4D genome.
PG  - 233-245
AB  - In eukaryotes, the genome is hierarchically packed inside the nucleus, which 
      facilitates physical contact between cis-regulatory elements (CREs), such as 
      enhancers and promoters. Accumulating evidence highlights the critical role of 
      higherorder chromatin structure in precise regulation of spatiotemporal gene 
      expression under diverse biological contexts including lineage commitment and 
      cell activation by external stimulus. Genomics and imaging-based technologies, 
      such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the 
      key principles of genome folding, while newly developed tools focus on 
      improvement in resolution, throughput and modality at single-cell and population 
      levels, and challenge the knowledge obtained through conventional approaches. In 
      this review, we discuss recent advances in our understanding of principles of 
      higher-order chromosome conformation and technologies to investigate 4D chromatin 
      interactions. [BMB Reports 2021; 54(5): 233-245].
FAU - Jung, Namyoung
AU  - Jung N
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang 37673, Korea.
FAU - Kim, Tae-Kyung
AU  - Kim TK
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang 37673; Yonsei University, Seoul 03722, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - BMB Rep
JT  - BMB reports
JID - 101465334
RN  - 0 (Chromatin)
SB  - IM
MH  - Chromatin/*genetics/metabolism
MH  - Humans
MH  - Promoter Regions, Genetic/genetics
PMC - PMC8167246
COIS- CONFLICTS OF INTEREST The authors have no conflicting interests.
EDAT- 2021/05/12 06:00
MHDA- 2021/11/30 06:00
PMCR- 2021/05/31
CRDT- 2021/05/11 05:46
PHST- 2021/02/19 00:00 [received]
PHST- 2021/05/12 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2021/05/11 05:46 [entrez]
PHST- 2021/05/31 00:00 [pmc-release]
AID - 5322 [pii]
AID - bmb-54-5-233 [pii]
AID - 10.5483/BMBRep.2021.54.5.035 [doi]
PST - ppublish
SO  - BMB Rep. 2021 May;54(5):233-245. doi: 10.5483/BMBRep.2021.54.5.035.