PMID- 33972923
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210513
IS  - 2219-2808 (Print)
IS  - 2219-2808 (Electronic)
IS  - 2219-2808 (Linking)
VI  - 10
IP  - 3
DP  - 2021 May 9
TI  - Repetitiveness of the oral glucose tolerance test in children and adolescents.
PG  - 29-39
LID - 10.5409/wjcp.v10.i3.29 [doi]
AB  - BACKGROUND: Data regarding the most suitable diagnostic method for the diagnosis 
      of glucose impairment in asymptomatic children and adolescents are inconclusive. 
      Furthermore, limited data are available on the reproducibility of the oral 
      glucose tolerance test (OGTT) in children and adolescents who are obese (OB). 
      AIM: To investigate the usefulness of the OGTT as a screening method for glucose 
      dysregulation in children and adolescents. METHODS: Eighty-one children and 
      adolescents, 41 females, either overweight (OW), OB or normal weight (NW) but 
      with a strong positive family history of type 2 diabetes mellitus (T2DM), were 
      enrolled in the present observational study from the Outpatient Clinic of 
      Paediatric Endocrinology of the University Hospital of Patras in Greece. One or 
      two 3-h OGTTs were performed and glucose, insulin and C-peptide concentrations 
      were measured at several time points (t = 0 min, t = 15 min, t = 30 min, t = 60 
      min, t = 90 min, t = 120 min, t = 180 min). RESULTS: Good repetitiveness was 
      observed in the OGTT response with regard to T2DM, while low repetitiveness was 
      noted in the OGTT response with regard to impaired glucose tolerance (IGT) and no 
      repetitiveness with regard to impaired fasting glucose (IFG). In addition, no 
      concordance was observed between IFG and IGT. During the 1(st) and 2(nd) OGTTs, 
      no significant difference was found in the glucose concentrations between NW, OW 
      and OB patients, whereas insulin and C-peptide concentrations were higher in OW 
      and OB compared to NW patients at several time points during the OGTTs. Also, OW 
      and OB patients showed a worsening insulin and C-peptide response during the 
      2(nd) OGTT as compared to the 1(st) OGTT. CONCLUSION: In mild or moderate 
      disorders of glucose metabolism, such as IFG and IGT, a diagnosis may not be 
      reached using only one OGTT, and a second test or additional investigations may 
      be needed. When glucose metabolism is profoundly impaired, as in T2DM, one OGTT 
      is probably more reliable and adequate for establishing the diagnosis. Excessive 
      weight and/or a positive family history of T2DM possibly affect the insulin and 
      C-peptide response in the OGTT from a young age.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Kostopoulou, Eirini
AU  - Kostopoulou E
AD  - Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, 
      University of Patras School of Medicine, Patras 26504, Greece. 
      irekost@upatras.gr.
FAU - Skiadopoulos, Spyridon
AU  - Skiadopoulos S
AD  - Department of Medical Physics, School of Medicine, University of Patras, Patras 
      26504, Greece.
FAU - Partsalaki, Ioanna
AU  - Partsalaki I
AD  - Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, 
      University of Patras School of Medicine, Patras 26504, Greece.
FAU - Rojas Gil, Andrea Paola
AU  - Rojas Gil AP
AD  - Department of Nursing, University of Peloponnese, Tripolis 22100, Greece.
FAU - Spiliotis, Bessie E
AU  - Spiliotis BE
AD  - Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, 
      University of Patras School of Medicine, Patras 26504, Greece.
LA  - eng
PT  - Journal Article
DEP - 20210509
PL  - United States
TA  - World J Clin Pediatr
JT  - World journal of clinical pediatrics
JID - 101627548
PMC - PMC8085718
OTO - NOTNLM
OT  - Adolescents
OT  - Children
OT  - Impaired fasting glucose
OT  - Impaired glucose tolerance
OT  - Obesity
OT  - Oral glucose tolerance test
COIS- Conflict-of-interest statement: The authors have no conflicts of interest to 
      report.
EDAT- 2021/05/12 06:00
MHDA- 2021/05/12 06:01
PMCR- 2021/05/09
CRDT- 2021/05/11 06:36
PHST- 2020/12/25 00:00 [received]
PHST- 2021/01/25 00:00 [revised]
PHST- 2021/03/07 00:00 [accepted]
PHST- 2021/05/11 06:36 [entrez]
PHST- 2021/05/12 06:00 [pubmed]
PHST- 2021/05/12 06:01 [medline]
PHST- 2021/05/09 00:00 [pmc-release]
AID - 10.5409/wjcp.v10.i3.29 [doi]
PST - epublish
SO  - World J Clin Pediatr. 2021 May 9;10(3):29-39. doi: 10.5409/wjcp.v10.i3.29. 
      eCollection 2021 May 9.