PMID- 33973131
OWN - NLM
STAT- MEDLINE
DCOM- 20210906
LR  - 20210906
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 476
IP  - 9
DP  - 2021 Sep
TI  - The protective potential of alpha lipoic acid on amiodarone-induced pulmonary 
      fibrosis and hepatic injury in rats.
PG  - 3433-3448
LID - 10.1007/s11010-021-04173-7 [doi]
AB  - Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac 
      tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis 
      (PF) and hepatotoxicity. This study aimed to investigate the influence of alpha 
      lipoic acid (ALA) on AMD-induced PF and hepatotoxicity in male Wistar rats. AMD 
      administration resulted in elevated lung contents of hydroxyproline (Hyp), 
      malondialdehyde (MDA), and increased serum levels of transforming growth factor 
      beta-1 (TGF-beta1), interferon-gamma (IFN-gamma), alanine amino transaminase (ALT), 
      aspartate amino transaminase (AST), total cholesterol (TC), and glucose. On the 
      other side, lung content of glutathione reduced (GSH) and serum levels of total 
      anti-oxidant capacity (TAC) were significantly decreased. Histopathologically, 
      AMD caused PF, produced a mild hepatic injury, and increased expression of alpha 
      smooth muscle actin (alpha-SMA). Treatment with ALA produced a significant reversal 
      of the oxidative stress, fibrosis, and inflammation parameters with reductions in 
      alpha-SMA expressions, leading to amelioration of histopathological lesions. ALA 
      might provide supportive therapy in AMD-receiving cardiovascular patients.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Ibrahim Fouad, Ghadha
AU  - Ibrahim Fouad G
AUID- ORCID: 0000-0003-3665-3153
AD  - Department of Therapeutic Chemistry, National Research Centre, 33 El-Bohouth St., 
      Dokki, Cairo, 12622, Egypt. ghadhaibrahim@yahoo.com.
FAU - R Mousa, Mohamed
AU  - R Mousa M
AD  - Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 
      12211, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20210510
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Protective Agents)
RN  - 0 (Vasodilator Agents)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - GAN16C9B8O (Glutathione)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - Alanine Transaminase/metabolism
MH  - Amiodarone/*toxicity
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Chemical and Drug Induced Liver Injury/etiology/metabolism/pathology/*prevention 
      & control
MH  - Cytokines/metabolism
MH  - Glutathione/metabolism
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress
MH  - Protective Agents/*pharmacology
MH  - Pulmonary Fibrosis/chemically induced/metabolism/pathology/*prevention & control
MH  - Rats
MH  - Rats, Wistar
MH  - Thioctic Acid/*pharmacology
MH  - Vasodilator Agents/toxicity
OTO - NOTNLM
OT  - Alpha lipoic acid
OT  - Amiodarone
OT  - Hepatotoxicity
OT  - Hydroxyproline
OT  - Pulmonary fibrosis
OT  - Transforming growth factor beta-1 (TGF-beta1)
EDAT- 2021/05/12 06:00
MHDA- 2021/09/07 06:00
CRDT- 2021/05/11 06:42
PHST- 2021/01/07 00:00 [received]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/05/12 06:00 [pubmed]
PHST- 2021/09/07 06:00 [medline]
PHST- 2021/05/11 06:42 [entrez]
AID - 10.1007/s11010-021-04173-7 [pii]
AID - 10.1007/s11010-021-04173-7 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2021 Sep;476(9):3433-3448. doi: 10.1007/s11010-021-04173-7. 
      Epub 2021 May 10.