PMID- 33976398
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20230502
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 36
IP  - 5
DP  - 2022 May
TI  - Evaluation of outer nuclear layer overshadowed by retinal vessels in retinitis 
      pigmentosa.
PG  - 1042-1049
LID - 10.1038/s41433-021-01578-y [doi]
AB  - OBJECTIVES: We investigated in vivo light-induced photoreceptor damage in 
      retinitis pigmentosa (RP) using spectral-domain optical coherence tomography 
      (SD-OCT) images. METHODS: We retrospectively reviewed patients with genetic 
      diagnosis of EYS-associated RP. The outer nuclear layer (ONL) thickness under 
      retinal vessels was measured on SD-OCT vertical scans. As a control, we measured 
      adjacent ONL thickness 100 mum superior and inferior from the vessel. Same 
      measurements were performed in healthy subjects. We calculated the ratio of ONL 
      thickness under vessel divided by the average of adjacent ONL thickness and 
      defined as ONL preservation ratio. In patients with RP, the length of ellipsoid 
      zone (EZ) from the fovea was also measured with SD-OCT vertical scans. RESULTS: 
      Thirty EYS-associated RP patients and 25 healthy subjects were included. In both 
      groups, ONL thickness overshadowed by retinal vessels was not significantly 
      different from that of adjacent area. However, ONL preservation ratio of RP was 
      larger than that of healthy control in both superior and inferior retina (1.03 vs 
      0.97; p < 0.01, 1.15 vs 0.95; p < 0.01, respectively). In RP, ONL preservation 
      ratio was significantly larger in the inferior retina than superior retina 
      (p < 0.01). Furthermore, in RP patients, the EZ length from the fovea was always 
      shorter in the inferior than superior retina and there was a significant 
      difference (p < 0.01). CONCLUSIONS: Patients with EYS-associated RP exhibited 
      inferior-dominant photoreceptor death and the relative ONL preservation under 
      retinal vessels. These results suggest that longitudinal environment light 
      exposure may be correlated with the photoreceptor death.
CI  - (c) 2021. The Author(s), under exclusive licence to The Royal College of 
      Ophthalmologists.
FAU - Otsuka, Yuki
AU  - Otsuka Y
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Oishi, Akio
AU  - Oishi A
AUID- ORCID: 0000-0002-0977-9458
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan. aquio@kuhp.kyoto-u.ac.jp.
FAU - Miyata, Manabu
AU  - Miyata M
AUID- ORCID: 0000-0002-7574-1749
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Uji, Akihito
AU  - Uji A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Oishi, Maho
AU  - Oishi M
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Hasegawa, Tomoko
AU  - Hasegawa T
AUID- ORCID: 0000-0002-5539-0099
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Numa, Shogo
AU  - Numa S
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Ikeda, Hanako Ohashi
AU  - Ikeda HO
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Tsujikawa, Akitaka
AU  - Tsujikawa A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210511
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
RN  - 0 (EYS protein, human)
RN  - 0 (Eye Proteins)
SB  - IM
MH  - Eye Proteins
MH  - Humans
MH  - Retina
MH  - Retinal Vessels/diagnostic imaging
MH  - *Retinitis Pigmentosa/diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
PMC - PMC9046433
COIS- YO, AO, MM, AU, MO, TH, SN and HOI: none; and AT: grant from Canon (Tokyo, Japan) 
      and JFC sales (Tokyo, Japan) and personal fee from Canon and Nidek (Gamagori, 
      Japan).
EDAT- 2021/05/13 06:00
MHDA- 2022/04/30 06:00
PMCR- 2023/05/01
CRDT- 2021/05/12 06:57
PHST- 2020/07/28 00:00 [received]
PHST- 2021/04/23 00:00 [accepted]
PHST- 2021/04/07 00:00 [revised]
PHST- 2021/05/13 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2021/05/12 06:57 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - 10.1038/s41433-021-01578-y [pii]
AID - 1578 [pii]
AID - 10.1038/s41433-021-01578-y [doi]
PST - ppublish
SO  - Eye (Lond). 2022 May;36(5):1042-1049. doi: 10.1038/s41433-021-01578-y. Epub 2021 
      May 11.