PMID- 33976639
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210514
IS  - 1662-6575 (Print)
IS  - 1662-6575 (Electronic)
IS  - 1662-6575 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Jan-Apr
TI  - Intrachromosomal Amplification of Chromosome 21 in Childhood Acute Lymphoblastic 
      Leukemia: Study of 3 Cases.
PG  - 592-598
LID - 10.1159/000514107 [doi]
AB  - Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. 
      The presence or absence of a characteristic genetic abnormality usually observed 
      in childhood ALL plays a very important role in determining the prognosis and 
      stratification for treatment. Intrachromosomal amplification of chromosome 21 
      (iAMP21) is an uncommon high-risk chromosomal abnormality than can occur only in 
      2% of childhood B-cell precursor lymphoblastic leukemia. Molecular genetic 
      analysis and the fluorescence in situ hybridization (FISH) technique are the 
      basic methods used to detect the presence of the most common genetic 
      abnormalities, the presence or absence of which has an impact on the patient's 
      classification into the appropriate risk group. This work presents 3 BCP-ALL 
      iAMP21-positive patients who were detected during routine genetic diagnostics 
      using the FISH method and microarray test. iAMP21 is associated with a poor 
      prognosis and high risk for relapse. Children with B-cell precursor lymphoblastic 
      leukemia with this genetic entity are associated with a delayed treatment 
      response. The FISH method and single-nucleotide polymorphism array provides a 
      useful method to detect characteristic genetic changes.
CI  - Copyright (c) 2021 by S. Karger AG, Basel.
FAU - Mroczkowska, Aleksandra
AU  - Mroczkowska A
AD  - Laboratory of Genetic Diagnostics, University Children's Hospital, Lublin, 
      Poland.
AD  - Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, 
      Laboratory of Molecular Biology and Cytogenetics, Wroclaw Medical University, 
      Wroclaw, Poland.
FAU - Lejman, Monika
AU  - Lejman M
AD  - Laboratory of Genetic Diagnostics, Medical University of Lublin, Lublin, Poland.
LA  - eng
PT  - Case Reports
DEP - 20210329
PL  - Switzerland
TA  - Case Rep Oncol
JT  - Case reports in oncology
JID - 101517601
PMC - PMC8077425
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia
OT  - Fluorescence in situ hybridization
OT  - Intrachromosomal amplification of chromosome 21
OT  - Single-nucleotide polymorphismarray
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/05/13 06:00
MHDA- 2021/05/13 06:01
PMCR- 2021/03/29
CRDT- 2021/05/12 07:03
PHST- 2020/12/17 00:00 [received]
PHST- 2020/12/20 00:00 [accepted]
PHST- 2021/05/12 07:03 [entrez]
PHST- 2021/05/13 06:00 [pubmed]
PHST- 2021/05/13 06:01 [medline]
PHST- 2021/03/29 00:00 [pmc-release]
AID - cro-0014-0592 [pii]
AID - 10.1159/000514107 [doi]
PST - epublish
SO  - Case Rep Oncol. 2021 Mar 29;14(1):592-598. doi: 10.1159/000514107. eCollection 
      2021 Jan-Apr.