PMID- 33976934
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2090-8016 (Print)
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2021
DP  - 2021
TI  - Cardiovascular Organ Damage in Clinical Subtypes of Systemic Sclerosis: Arterial 
      Stiffness and Echocardiography Might Not Be the Ideal Tools for Patient Risk 
      Stratification.
PG  - 7915890
LID - 10.1155/2021/7915890 [doi]
LID - 7915890
AB  - BACKGROUND: Vascular damage is recognized as a diagnostic landmark in systemic 
      sclerosis (SSc), both in its limited and diffuse subtypes. Early detection at a 
      subclinical stage with transthoracic echocardiography (TTE) and carotid femoral 
      pulse wave velocity (cfPWV) may be helpful in therapeutic planning and 
      management. Aim of the Study. The aim of the study was to evaluate presence of 
      subclinical cardiovascular damage in patients with limited and diffuse SSc in 
      comparison with a cohort of healthy individuals. METHODS: Consecutive patients 
      with limited and diffuse SSc underwent complete TTE and cfPWV and a complete 
      review of clinical data. As controls, 23 healthy subjects with similar 
      hemodynamic profiles were selected. RESULTS: 41 patients (35 female, aged 56.9 
      years), 21 with diffuse and 20 with limited SSc, were recruited. Past medical 
      history, cardiovascular risk factors, gender distribution, and disease duration 
      were similar in the two groups as well as TTE parameters and hemodynamic 
      indexes-cfPWV (6.5 [6-6.8] vs. 7.0 [6.2-8.5], p=0.24) and augmentation index 
      (145.6 +/- 14.2 vs. 149 +/- 20.6, p=0.52). Patients with limited SSc were 10 years 
      older than patients with diffuse SSc. In the multiple regression analysis, only 
      age (p=0.0154) and disease duration (p=0.0467) resulted as the significant 
      determinant of cfPWV. When compared to healthy controls, no significant 
      difference emerged in TTE or hemodynamic indexes. CONCLUSION: In SSc, cfPWV 
      increases with age, with no additional impact of pathology or subtype. Vascular 
      damage in the SSc population is not accurately reflected in increased arterial 
      stiffness, as evaluated with cfPWV, or classically defined echocardiographic 
      findings of organ damage (i.e., left ventricular concentric remodelling and 
      increased filling pressures).
CI  - Copyright (c) 2021 Eleonora Avenatti et al.
FAU - Avenatti, Eleonora
AU  - Avenatti E
AUID- ORCID: 0000-0002-7153-3790
AD  - Internal Medicine and Hypertension Division, Department of Medical Sciences, AOU 
      Citta' Salute e Scienza of Turin, University of Turin, Turin, Italy.
FAU - Bruno, Giulia
AU  - Bruno G
AUID- ORCID: 0000-0002-5733-1180
AD  - Internal Medicine and Hypertension Division, Department of Medical Sciences, AOU 
      Citta' Salute e Scienza of Turin, University of Turin, Turin, Italy.
FAU - Priora, Marta
AU  - Priora M
AUID- ORCID: 0000-0002-9194-9179
AD  - Rheumatology Unit, AOU Citta' Salute e Scienza of Turin, University of Turin, 
      Turin, Italy.
FAU - Parisi, Simone
AU  - Parisi S
AUID- ORCID: 0000-0003-4496-8315
AD  - Rheumatology Unit, AOU Citta' Salute e Scienza of Turin, University of Turin, 
      Turin, Italy.
FAU - Ballini, Chiara
AU  - Ballini C
AUID- ORCID: 0000-0001-8060-9067
AD  - Rheumatology Unit, AOU Citta' Salute e Scienza of Turin, University of Turin, 
      Turin, Italy.
FAU - Veglio, Franco
AU  - Veglio F
AUID- ORCID: 0000-0002-6654-6247
AD  - Internal Medicine and Hypertension Division, Department of Medical Sciences, AOU 
      Citta' Salute e Scienza of Turin, University of Turin, Turin, Italy.
FAU - Milan, Alberto
AU  - Milan A
AUID- ORCID: 0000-0002-8863-8572
AD  - Internal Medicine and Hypertension Division, Department of Medical Sciences, AOU 
      Citta' Salute e Scienza of Turin, University of Turin, Turin, Italy.
FAU - Fusaro, Enrico
AU  - Fusaro E
AUID- ORCID: 0000-0001-9888-2563
AD  - Rheumatology Unit, AOU Citta' Salute e Scienza of Turin, University of Turin, 
      Turin, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210423
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC8087482
COIS- The authors declare no conflicts of interest.
EDAT- 2021/05/13 06:00
MHDA- 2021/05/13 06:01
PMCR- 2021/04/23
CRDT- 2021/05/12 07:05
PHST- 2020/05/12 00:00 [received]
PHST- 2021/02/06 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/05/12 07:05 [entrez]
PHST- 2021/05/13 06:00 [pubmed]
PHST- 2021/05/13 06:01 [medline]
PHST- 2021/04/23 00:00 [pmc-release]
AID - 10.1155/2021/7915890 [doi]
PST - epublish
SO  - Cardiol Res Pract. 2021 Apr 23;2021:7915890. doi: 10.1155/2021/7915890. 
      eCollection 2021.