PMID- 33977081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2214-2509 (Print)
IS  - 2214-2509 (Electronic)
IS  - 2214-2509 (Linking)
VI  - 24
DP  - 2021
TI  - Co-infection with coronavirus disease 2019, previously undiagnosed human 
      immunodeficiency virus, Pneumocystis jirovecii pneumonia and cytomegalovirus 
      pneumonitis, with possible immune reconstitution inflammatory syndrome.
PG  - e01153
LID - 10.1016/j.idcr.2021.e01153 [doi]
LID - e01153
AB  - BACKGROUND: Case reports, case series and cohort studies have been published 
      describing the clinical course and outcomes of people living with human 
      immunodeficiency virus (PLWH) who contract coronavirus disease 2019 (COVID-19) 
      pneumonia. However, the majority of the published work focuses on patients with 
      well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy 
      (ART). CASE PRESENTATION: We present a case of a new diagnosis of HIV with 
      Acquired Immune Deficiency Syndrome (AIDS) made simultaneously to diagnosis of 
      COVID-19, with co-infection with pneumocystis jirovecii pneumonia (PJP) and 
      possible cytomegalovirus (CMV) pneumonitis. The patient decompensated following 
      initiation of ART, suggestive of possible immune reconstitution inflammatory 
      syndrome (IRIS). CONCLUSIONS: This case illustrates the importance of maintaining 
      a high suspicion for HIV/AIDS in patients with risk factors. Additionally, this 
      case raises the possibility that IRIS may develop in the setting of ART 
      initiation in patients with COVID-19.
CI  - (c) 2021 Published by Elsevier Ltd.
FAU - Merchant, Elisabeth A
AU  - Merchant EA
AD  - Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard 
      Medical School, 110 Francis Street, Suite GB, Boston, MA, 02215, USA.
FAU - Flint, Kristen
AU  - Flint K
AD  - Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, 330 Brookline Avenue, Boston, MA, 02215, USA.
FAU - Barouch, Dan H
AU  - Barouch DH
AD  - Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard 
      Medical School, 110 Francis Street, Suite GB, Boston, MA, 02215, USA.
AD  - Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, 
      Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02115, USA.
FAU - Blair, Barbra M
AU  - Blair BM
AD  - Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard 
      Medical School, 110 Francis Street, Suite GB, Boston, MA, 02215, USA.
LA  - eng
PT  - Case Reports
DEP - 20210507
PL  - Netherlands
TA  - IDCases
JT  - IDCases
JID - 101634540
PMC - PMC8103711
OTO - NOTNLM
OT  - AIDS
OT  - COVID-19
OT  - HIV
OT  - IRIS
OT  - PJP
COIS- The authors report no declarations of interest.
EDAT- 2021/05/13 06:00
MHDA- 2021/05/13 06:01
PMCR- 2021/05/07
CRDT- 2021/05/12 07:06
PHST- 2021/03/02 00:00 [received]
PHST- 2021/05/04 00:00 [revised]
PHST- 2021/05/04 00:00 [accepted]
PHST- 2021/05/13 06:00 [pubmed]
PHST- 2021/05/13 06:01 [medline]
PHST- 2021/05/12 07:06 [entrez]
PHST- 2021/05/07 00:00 [pmc-release]
AID - S2214-2509(21)00109-8 [pii]
AID - e01153 [pii]
AID - 10.1016/j.idcr.2021.e01153 [doi]
PST - ppublish
SO  - IDCases. 2021;24:e01153. doi: 10.1016/j.idcr.2021.e01153. Epub 2021 May 7.