PMID- 33978069
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20210519
IS  - 1678-2690 (Electronic)
IS  - 0001-3765 (Linking)
VI  - 93
IP  - 3
DP  - 2021
TI  - Water-soluble lectin (WSMoL) from Moringa oleifera seeds treatment recovers 
      glycemic levels and improves left ventricular ejection fraction on Type-2 
      Diabetes mice model.
PG  - e20201596
LID - S0001-37652021000500601 [pii]
LID - 10.1590/0001-3765202120201596 [doi]
AB  - Moringa oleifera, a plant widely used in traditional medicine as well as for 
      water purification, contains a lectin on its seeds named WSMoL which modulates 
      several immune characteristics and has shown cardiac safe properties. Here, we 
      tested the hypothesis that WSMoL is able to recover fasting glucose levels and to 
      improve the cardiac left ventricular (LV) function in a type 2 diabetes mellitus 
      (T2DM) mice model. T2DM was induced in adult C57BL/6 mice by combining a high fat 
      diet and low doses of Streptozotocin. Mice were randomly divided in two groups: 
      i. received WSMoL for 21 consecutive days by gavage (T2DM + WSMoL) and ii. 
      received saline solution (T2DM). Metabolic parameters and LV function were 
      assessed. WSMoL was able to reduce fasting blood glucose levels in T2DM mice 
      after 2 weeks of treatment, when compared to T2DM untreated group. Regarding to 
      cardiac LV function, the T2DM + WSMoL group depicted ejection fraction values 
      comparable to non-diabetic group. Our results show: i. WSMoL treatment presented 
      a potent hypoglycemic effect decreasing insulin resistance and ii. WSMoL was able 
      to improve cardiac LV ejection fraction. Collectively, the results presented here 
      show WSMoL as a potential hypoglycemic agent to be tested in T2DM patients.
FAU - Vera-Nunez, Narendra
AU  - Vera-Nunez N
AUID- ORCID: 0000-0001-7247-2697
AD  - Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas 
      Filho, Centro de Ciencias da Saude, Av. Carlos Chagas Filho, 373, Ilha do Fundao, 
      21941-902 Rio de Janeiro, RJ, Brazil.
FAU - Guirao, Ainhoa R Y
AU  - Guirao ARY
AUID- ORCID: 0000-0002-5920-7028
AD  - Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas 
      Filho, Centro de Ciencias da Saude, Av. Carlos Chagas Filho, 373, Ilha do Fundao, 
      21941-902 Rio de Janeiro, RJ, Brazil.
FAU - Silva, Jose Dayvid F DA
AU  - Silva JDFD
AUID- ORCID: 0000-0001-6274-7968
AD  - Universidade Federal de Pernambuco, Departamento de Bioquimica, Centro de 
      Biociencias, Av. Prof. Moraes Rego, 1235, Cidade Universitaria, 50670-420 Recife, 
      PE, Brazil.
FAU - Ramos, Isalira P
AU  - Ramos IP
AUID- ORCID: 0000-0003-3577-0403
AD  - Universidade Federal do Rio de Janeiro, Centro Nacional de Biologia Estrutural e 
      Bioimagem-CENABIO, Avenida Carlos Chagas Filho, 373, Ilha do Fundao, 21941-902 
      Rio de Janeiro, RJ, Brazil.
FAU - Torres, Marilia K S
AU  - Torres MKS
AUID- ORCID: 0000-0002-4239-6459
AD  - Universidade Federal de Pernambuco, Departamento de Bioquimica, Centro de 
      Biociencias, Av. Prof. Moraes Rego, 1235, Cidade Universitaria, 50670-420 Recife, 
      PE, Brazil.
FAU - Coelho, Luana Cassandra B B
AU  - Coelho LCBB
AUID- ORCID: 0000-0002-0065-2602
AD  - Universidade Federal de Pernambuco, Departamento de Bioquimica, Centro de 
      Biociencias, Av. Prof. Moraes Rego, 1235, Cidade Universitaria, 50670-420 Recife, 
      PE, Brazil.
FAU - Napoleao, Thiago Henrique
AU  - Napoleao TH
AUID- ORCID: 0000-0003-3467-708X
AD  - Universidade Federal de Pernambuco, Departamento de Bioquimica, Centro de 
      Biociencias, Av. Prof. Moraes Rego, 1235, Cidade Universitaria, 50670-420 Recife, 
      PE, Brazil.
FAU - Paiva, Patricia Maria G
AU  - Paiva PMG
AUID- ORCID: 0000-0002-1013-0023
AD  - Universidade Federal de Pernambuco, Departamento de Bioquimica, Centro de 
      Biociencias, Av. Prof. Moraes Rego, 1235, Cidade Universitaria, 50670-420 Recife, 
      PE, Brazil.
FAU - Medei, Emiliano
AU  - Medei E
AUID- ORCID: 0000-0002-0044-1311
AD  - Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas 
      Filho, Centro de Ciencias da Saude, Av. Carlos Chagas Filho, 373, Ilha do Fundao, 
      21941-902 Rio de Janeiro, RJ, Brazil.
AD  - Universidade Federal do Rio de Janeiro, Centro Nacional de Biologia Estrutural e 
      Bioimagem-CENABIO, Avenida Carlos Chagas Filho, 373, Ilha do Fundao, 21941-902 
      Rio de Janeiro, RJ, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210510
PL  - Brazil
TA  - An Acad Bras Cienc
JT  - Anais da Academia Brasileira de Ciencias
JID - 7503280
RN  - 0 (Lectins)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - Lectins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Moringa oleifera
MH  - Seeds
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - Water
EDAT- 2021/05/13 06:00
MHDA- 2021/05/20 06:00
CRDT- 2021/05/12 08:56
PHST- 2020/10/04 00:00 [received]
PHST- 2021/01/06 00:00 [accepted]
PHST- 2021/05/12 08:56 [entrez]
PHST- 2021/05/13 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
AID - S0001-37652021000500601 [pii]
AID - 10.1590/0001-3765202120201596 [doi]
PST - epublish
SO  - An Acad Bras Cienc. 2021 May 10;93(3):e20201596. doi: 
      10.1590/0001-3765202120201596. eCollection 2021.