PMID- 33979806
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 1662-4033 (Electronic)
IS  - 1662-4025 (Print)
IS  - 1662-4025 (Linking)
VI  - 14
IP  - 3
DP  - 2021
TI  - Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic 
      Ovary Syndrome.
PG  - 283-290
LID - 10.1159/000515294 [doi]
AB  - INTRODUCTION: Adult obesity is linked with polycystic ovary syndrome (PCOS), but 
      the importance of body size at ages before PCOS is diagnosed is unknown. 
      OBJECTIVE: To investigate associations between a woman's own birthweight, 
      childhood body mass index (BMI), height and growth patterns in relation to her 
      risk of PCOS. METHODS: We included 65,665 girls from the Copenhagen School Health 
      Records Register, born in the period 1960-1996, with information on birthweight 
      and measured weight and height at the ages of 7-13 years. Overweight was defined 
      using International Obesity Task Force (IOTF) criteria. From the Danish National 
      Patient Register, 606 women aged 15-50 years were identified. Hazard ratios (HRs) 
      and 95% confidence intervals (CIs) were estimated by Cox regression analysis. 
      RESULTS: Birthweight was not associated with PCOS. At the age of 7-13 years, 
      girls with overweight had a higher risk of developing PCOS than girls without 
      overweight; HR 2.83 (95% CI 2.34-3.42) at age 7 years and 2.99 (95% CI 2.38-3.76) 
      at age 13 years. Furthermore, girls with overweight at both 7 and 13 years had a 
      higher risk of developing PCOS than girls without overweight or overweight at 
      only one age. Height was positively associated with PCOS risk at all ages. Girls 
      who were persistently tall or changed from tall to average height had a higher 
      risk of developing PCOS than girls with average height growth. CONCLUSION: 
      Overweight and tall stature in childhood are positively associated with PCOS 
      risk, but birthweight is not.
CI  - (c) 2021 The Author(s) Published by S. Karger AG, Basel.
FAU - Aarestrup, Julie
AU  - Aarestrup J
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, The Capital Region, Frederiksberg, Denmark.
FAU - Pedersen, Dorthe C
AU  - Pedersen DC
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, The Capital Region, Frederiksberg, Denmark.
FAU - Thomas, Peter E
AU  - Thomas PE
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, The Capital Region, Frederiksberg, Denmark.
FAU - Glintborg, Dorte
AU  - Glintborg D
AD  - Department of Endocrinology and Metabolism, Odense University Hospital, 
      University of Southern Denmark, Odense, Denmark.
FAU - Holm, Jens-Christian
AU  - Holm JC
AD  - The Children's Obesity Clinic, European Center of Management (EASO), Department 
      of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
AD  - Novo Nordisk Foundation Center for Basic Metabolic Research, Human Genomics and 
      Metagenomics in Metabolism, Faculty of Health and Medical Sciences, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Bjerregaard, Lise G
AU  - Bjerregaard LG
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, The Capital Region, Frederiksberg, Denmark.
FAU - Baker, Jennifer L
AU  - Baker JL
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, The Capital Region, Frederiksberg, Denmark.
AD  - Novo Nordisk Foundation Center for Basic Metabolic Research, Human Genomics and 
      Metagenomics in Metabolism, Faculty of Health and Medical Sciences, University of 
      Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210512
PL  - Switzerland
TA  - Obes Facts
JT  - Obesity facts
JID - 101469429
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Birth Weight
MH  - Body Height
MH  - Body Mass Index
MH  - Child
MH  - Female
MH  - Humans
MH  - Overweight/epidemiology
MH  - *Polycystic Ovary Syndrome/epidemiology
MH  - Risk Factors
PMC - PMC8255636
OTO - NOTNLM
OT  - Birthweight
OT  - Body height
OT  - Body weights and measures
OT  - Child
OT  - Polycystic ovary syndrome
COIS- Dr. Jens-Christian Holm reports obesity related services to patients and health 
      care professionals. All other authors have no declarations.
EDAT- 2021/05/13 06:00
MHDA- 2021/11/26 06:00
PMCR- 2021/05/12
CRDT- 2021/05/12 20:15
PHST- 2020/10/07 00:00 [received]
PHST- 2021/02/15 00:00 [accepted]
PHST- 2021/05/13 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/05/12 20:15 [entrez]
PHST- 2021/05/12 00:00 [pmc-release]
AID - 000515294 [pii]
AID - ofa-0014-0283 [pii]
AID - 10.1159/000515294 [doi]
PST - ppublish
SO  - Obes Facts. 2021;14(3):283-290. doi: 10.1159/000515294. Epub 2021 May 12.