PMID- 33980344
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20220304
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 42
IP  - 3
DP  - 2021 May 1
TI  - Clinical phenotypes of childhood food allergies based on immune mechanisms: A 
      multicenter study.
PG  - e86-e95
LID - 10.2500/aap.2021.42.210005 [doi]
AB  - Background: Food allergies (FA) are an important public health concern that place 
      a major burden on the lives of children and their families. The complex 
      pathogenesis of FAs results in multisystemic and heterogenous clinical 
      presentations. Objective: To evaluate, according to immune mechanisms, the 
      characteristics and risk factors of childhood FA in Turkey. Methods: This 
      descriptive multicenter study included 1248 children with FA, aged < 18 years,, 
      who were evaluated by pediatric allergists in 26 different centers. Results: 
      Immune mechanisms of FA were immunoglobulin E (IgE) mediated in 71.8%, non-IgE 
      mediated in 15.5%, and mixed IgE/non-IgE mediated in 12.7% of the patients. An 
      episode of anaphylaxis had occurred in 17.6% of IgE-mediated FA. The most common 
      food allergens were classified into five categories (in order of decreasing 
      frequency): cow's milk, egg, tree nuts and/or peanut, wheat, and seafood. 
      Allergies to cow's milk and egg declined significantly with age, whereas tree 
      nuts and/or peanut allergies increased with age. The 0-2 year age group accounted 
      for 62.5% of the cases. The most frequent cause of FA and food anaphylaxis was 
      cow's milk before age 13 years and tree nuts and/or peanut during adolescence 
      (ages 13-18 years). Compared with other phenotypes, male sex (odds ratio [OR] 
      1.486; p = 0.032), sibling(s) (OR 1.581; p = 0.021), and maternal atopy (OR 
      1.531; p = 0.045) increased the likelihood of IgE-mediated FA, whereas high 
      household income (OR 1.862; p = 0.026) increased the likelihood of 
      non-IgE-mediated FA in multivariate regression analysis. Conclusion: This study 
      showed that the clinical findings of FA were highly variable, depending on age 
      and underlying immune mechanism. Knowing the population characteristics will 
      enable better management of FA in children.
FAU - Bingol, Aysen
AU  - Bingol A
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Uygun, Dilara Fatma Kocacik
AU  - Uygun DFK
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Akdemir, Meltem
AU  - Akdemir M
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Erengin, Hakan
AU  - Erengin H
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Buyuktiryaki, Betul
AU  - Buyuktiryaki B
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Sackesen, Cansin
AU  - Sackesen C
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Bingol, Gulbin
AU  - Bingol G
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Orhan, Fazil
AU  - Orhan F
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Sekerel, Bulent Enis
AU  - Sekerel BE
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Arikoglu, Tugba
AU  - Arikoglu T
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
FAU - Altintas, Derya Ufuk
AU  - Altintas DU
AD  - The affiliations of the members of the writing committee and the names of all the 
      authors are provided in the online appendix.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens
MH  - Anaphylaxis/diagnosis/epidemiology/etiology
MH  - Animals
MH  - Arachis
MH  - Cattle
MH  - Child
MH  - Female
MH  - *Food Hypersensitivity/diagnosis/epidemiology
MH  - Humans
MH  - Immunoglobulin E
MH  - Male
MH  - Phenotype
EDAT- 2021/05/14 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/05/13 05:38
PHST- 2021/05/13 05:38 [entrez]
PHST- 2021/05/14 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
AID - 10.2500/aap.2021.42.210005 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2021 May 1;42(3):e86-e95. doi: 10.2500/aap.2021.42.210005.