PMID- 33981526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210514
IS  - 2189-8448 (Print)
IS  - 2189-8448 (Electronic)
IS  - 2189-8448 (Linking)
VI  - 24
IP  - 1
DP  - 2021
TI  - Estimation of minimal clinically important difference for quadriceps and 
      inspiratory muscle strength in older outpatients with chronic obstructive 
      pulmonary disease: a prospective cohort study.
PG  - 35-42
LID - 10.1298/ptr.E10049 [doi]
AB  - OBJECTIVE: To estimate the minimal clinically important difference (MCID) of 
      quadriceps and inspiratory muscle strength after a home-based pulmonary 
      rehabilitation program (PRP) in chronic obstructive pulmonary disease (COPD). 
      METHOD: Eighty-five COPD patients were included. Quadriceps maximal voluntary 
      contraction (QMVC) was measured. We measured maximal inspiratory mouth pressure 
      (PImax), the 6-minute walk distance (6MWD), the chronic respiratory questionnaire 
      (CRQ) and the modified Medical Research Council dyspnoea score (mMRC). All 
      measurements were conducted at baseline and at the end of the PRP. The MCID was 
      calculated using anchor-based (using 6MWD, CRQ, and mMRC as possible anchor 
      variables) and distribution-based (half standard deviation and 1.96 standard 
      error of measurement) approaches. Changes in the five variables were compared in 
      patients with and without changes in QMVC or PImax >MCID for each variable. 
      RESULTS: Sixty-nine COPD patients (age 75+/-6 years) were analysed. QMVC improved 
      by 2.4 (95%CI 1.1-3.7) kgf, PImax by 5.8 (2.7-8.8) cmH(2)O, 6MWD by 21 (11-32) 
      meters and CRQ by 3.9 (1.6-6.3) points. The MCID of QMVC and PImax was 3.3-7.5 
      kgf and 17.2-17.6 cmH(2)O, respectively. The MCID of QMVC (3.3 kgf) could 
      differentiate individuals with significant improvement in 6MWD and PImax from 
      those without. CONCLUSION: The MCID of QMVC (3.3 kgf) can identify a meaningful 
      change in quadriceps muscle strength after a PRP. The MCID of PImax (17.2 
      cmH(2)O) should be used with careful consideration, because the value is 
      estimated using distributionbased method.
CI  - 2021, JAPANESE PHYSICAL THERAPY ASSOCIATION.
FAU - Iwakura, Masahiro
AU  - Iwakura M
AD  - Department of Rehabilitation, Akita City Hospital, Japan.
FAU - Okura, Kazuki
AU  - Okura K
AD  - Department of Rehabilitation, Akita University Hospital, Japan.
FAU - Kubota, Mika
AU  - Kubota M
AD  - Department of Rehabilitation, Akita City Hospital, Japan.
FAU - Sugawara, Keiyu
AU  - Sugawara K
AD  - Department of Rehabilitation, Akita City Hospital, Japan.
FAU - Kawagoshi, Atsuyoshi
AU  - Kawagoshi A
AD  - Department of Rehabilitation, Akita City Hospital, Japan.
FAU - Takahashi, Hitomi
AU  - Takahashi H
AD  - Department of Physical Therapy, School of Health Science, International 
      University of Health and Welfare, Japan.
FAU - Shioya, Takanobu
AU  - Shioya T
AD  - Department of Physical Therapy, Akita University Graduate School of Health 
      Sciences, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201012
PL  - Japan
TA  - Phys Ther Res
JT  - Physical therapy research
JID - 101700769
PMC - PMC8111409
OTO - NOTNLM
OT  - chronic obstructive
OT  - minimal clinically important difference
OT  - muscle strength
OT  - quadriceps muscle
OT  - respiratory muscles
COIS- The authors have no competing interests to declare.
EDAT- 2021/05/14 06:00
MHDA- 2021/05/14 06:01
PMCR- 2020/10/12
CRDT- 2021/05/13 06:28
PHST- 2020/05/08 00:00 [received]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2021/05/13 06:28 [entrez]
PHST- 2021/05/14 06:00 [pubmed]
PHST- 2021/05/14 06:01 [medline]
PHST- 2020/10/12 00:00 [pmc-release]
AID - 10.1298/ptr.E10049 [doi]
PST - epublish
SO  - Phys Ther Res. 2020 Oct 12;24(1):35-42. doi: 10.1298/ptr.E10049. eCollection 
      2021.