PMID- 33982193
OWN - NLM
STAT- MEDLINE
DCOM- 20220211
LR  - 20220211
IS  - 1437-2320 (Electronic)
IS  - 0344-5607 (Linking)
VI  - 45
IP  - 1
DP  - 2022 Feb
TI  - The effect of local intraoperative corticosteroid application on postoperative 
      dysphagia following anterior cervical spine surgery.
PG  - 63-70
LID - 10.1007/s10143-019-01207-z [doi]
AB  - Dysphagia is a common complication following anterior cervical spine surgery 
      (ACSS). Although several literatures have reported the potential benefit of local 
      corticosteroid application on dysphagia, its safety and efficacy are still 
      unclear. A systematic review was performed aiming to evaluate the evidence of 
      local corticosteroid application in prevention or treatment of postoperative 
      dysphagia following ACSS. A systematic search was performed in September 2018 in 
      PubMed and Embase database. The following information was extracted: study 
      investigator, year of publication, number of patients, study design, 
      inclusion/exclusion criteria, administration protocol of steroid, type of 
      surgical procedure, number of levels performed, assessment methodology of 
      dysphagia, radiologic assessment of prevertebral soft tissue swelling (PSTS), 
      follow-up time points, outcome of dysphagia, and corticosteroid-related 
      complications. Qualitative synthesis was performed. Finally, 5 studies met the 
      inclusion/exclusion criteria. Four studies found that local corticosteroid 
      application could decrease the incidence and magnitude of postoperative dysphagia 
      while 1 study showed no effect on dysphagia significantly at 6 weeks and 3 months 
      follow-up time. A total of 2325 patients received local corticosteroid 
      intraoperatively; no early corticosteroid-related complication was reported. 
      Totally, 4 adverse events occurred in long-term follow-up time, including 2 bone 
      nonunion at 1.5 and 2.5 years postoperatively, 2 esophageal perforation at 2 
      months and 11 months of follow-up, respectively. Local corticosteroid application 
      can reduce the incidence and severity of dysphagia following ACSS without 
      increasing early corticosteroid-related complications. But further high-quality 
      study is necessary to analyze potential delayed complications.
CI  - (c) 2019. Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Cheng, Lei
AU  - Cheng L
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Guan, Jian
AU  - Guan J
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Zhang, Can
AU  - Zhang C
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Ma, Longbing
AU  - Ma L
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Yao, Qingyu
AU  - Yao Q
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Liu, Zhenlei
AU  - Liu Z
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Duan, Wanru
AU  - Duan W
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Jian, Fengzeng
AU  - Jian F
AUID- ORCID: 0000-0001-7860-278X
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China. fengzengjian@hotmail.com.
FAU - Wu, Hao
AU  - Wu H
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
FAU - Chen, Zan
AU  - Chen Z
AD  - Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience 
      Institute, Capital Medical University, 45 Changchun Street, Beijing, 100053, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20210512
PL  - Germany
TA  - Neurosurg Rev
JT  - Neurosurgical review
JID - 7908181
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Cervical Vertebrae/surgery
MH  - *Deglutition Disorders/drug therapy/etiology
MH  - Diskectomy
MH  - Humans
MH  - Postoperative Complications/drug therapy/prevention & control
MH  - *Spinal Fusion
OTO - NOTNLM
OT  - Anterior cervical spine surgery
OT  - Corticosteroid
OT  - Dysphagia
OT  - Systematic review
EDAT- 2021/05/14 06:00
MHDA- 2022/02/12 06:00
CRDT- 2021/05/13 06:40
PHST- 2019/07/09 00:00 [received]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2019/10/10 00:00 [revised]
PHST- 2021/05/14 06:00 [pubmed]
PHST- 2022/02/12 06:00 [medline]
PHST- 2021/05/13 06:40 [entrez]
AID - 10.1007/s10143-019-01207-z [pii]
AID - 10.1007/s10143-019-01207-z [doi]
PST - ppublish
SO  - Neurosurg Rev. 2022 Feb;45(1):63-70. doi: 10.1007/s10143-019-01207-z. Epub 2021 
      May 12.