PMID- 33982195
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 37
IP  - 10
DP  - 2021 Oct
TI  - Relationship among clinical characteristics, morphological culprit plaque 
      features, and long-term prognosis in patients with acute coronary syndrome.
PG  - 2827-2837
LID - 10.1007/s10554-021-02252-w [doi]
AB  - Culprit lesions of acute coronary syndrome (ACS) could be classified as plaque 
      rupture (PR), erosion, or calcified nodule (CN). We aimed to determine the 
      relationship among clinical characteristics, morphological plaque features, and 
      long-term prognosis in ACS. Patients with ACS, who underwent pre-intervention 
      optical coherence tomography between April 2013 and July 2018 were 
      retrospectively enrolled, and classified into the three groups based on the 
      culprit lesion morphology. In the 436 patients enrolled, incidences of PR, 
      erosion, and CN in ACS culprit lesions were 46.1, 39.9, and 14.0%, respectively. 
      Plaque erosion was more frequent in men aged < 60 years and CN was more frequent 
      in older adults in both sexes (>/= 80 years) (P < 0.001). Patients with CN had a 
      higher incidence of hemodialysis treatment (P < 0.001) and diabetes (P = 0.003). 
      Multivariate analysis revealed that ST elevation myocardial infarction (STEMI) 
      (P = 0.049) and presence of thin-cap fibroatheroma (TCFA) at the culprit lesion 
      were independently associated with PR; in younger patients (< 60 year), preserved 
      left ventricular ejection fraction and lower incidence of TCFA were correlated 
      with plaque erosion; and older age, non-STEMI, or unstable angina pectoris, 
      higher serum brain natriuretic peptide levels, and lower incidence of TCFA were 
      independently associated with CN. Multivariable analysis revealed that CN (odds 
      ratio [OR] 1.990, P = 0.005), male sex (OR 2.012, P = 0.004), and older age (OR 
      1.036, P < 0.001) were independently associated with future adverse events during 
      a median follow-up of 757 days. Different patient characteristics and 
      morphological features were associated with the type of culprit lesion in 
      patients with ACS.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Nagasawa, Akira
AU  - Nagasawa A
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Otake, Hiromasa
AU  - Otake H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan. hotake@med.kobe-u.ac.jp.
FAU - Kawamori, Hiroyuki
AU  - Kawamori H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Toba, Takayoshi
AU  - Toba T
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Sugizaki, Yoichiro
AU  - Sugizaki Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Takeshige, Ryo
AU  - Takeshige R
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Nakano, Shinsuke
AU  - Nakano S
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Tanimura, Kosuke
AU  - Tanimura K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Takahashi, Yu
AU  - Takahashi Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Fukuyama, Yusuke
AU  - Fukuyama Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
FAU - Kozuki, Amane
AU  - Kozuki A
AD  - Division of Cardiovascular Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, 
      Japan.
FAU - Shite, Junya
AU  - Shite J
AD  - Division of Cardiovascular Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, 
      Japan.
FAU - Iwasaki, Masamichi
AU  - Iwasaki M
AD  - Division of Cardiovascular Medicine, Hyogo Prefectural Awaji Medical Center, 
      Sumoto, Japan.
FAU - Kuroda, Koji
AU  - Kuroda K
AD  - Division of Cardiovascular Medicine, Hyogo Prefectural Awaji Medical Center, 
      Sumoto, Japan.
FAU - Takaya, Tomofumi
AU  - Takaya T
AD  - Division of Cardiovascular Medicine, Hyogo Prefectural Himeji Cardiovascular 
      Center, Himeji, Japan.
FAU - Hirata, Ken-Ichi
AU  - Hirata KI
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 
      650-0017, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210512
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - *Acute Coronary Syndrome/diagnostic imaging/therapy
MH  - Aged
MH  - Coronary Angiography
MH  - Coronary Vessels/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - *Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Tomography, Optical Coherence
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Calcified nodule
OT  - Optical coherence tomography
OT  - Plaque erosion
OT  - Plaque rupture
EDAT- 2021/05/14 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/05/13 06:40
PHST- 2021/01/07 00:00 [received]
PHST- 2021/04/21 00:00 [accepted]
PHST- 2021/05/14 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/05/13 06:40 [entrez]
AID - 10.1007/s10554-021-02252-w [pii]
AID - 10.1007/s10554-021-02252-w [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2021 Oct;37(10):2827-2837. doi: 
      10.1007/s10554-021-02252-w. Epub 2021 May 12.