PMID- 33982541
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 35
IP  - 1 Suppl. 2
DP  - 2021 Jan-Feb
TI  - Magnesium alginate in patients with laryngopharyngeal reflux.
PG  - 61-64
LID - 10.23812/21-1supp2-12 [doi]
AB  - Laryngopharyngeal reflux (LPR) is a common disease caused by the leaking beck of 
      gastric material out of the esophagus. The main symptoms are dysphonia, 
      dysphagia, and cough. There is an established use of proton pump inhibitors (PPI) 
      in patients with suspected LPR in common practice. This habit is translated by 
      the standard strategy to use PPI in treating patients with gastroesophageal 
      reflux. However, PPI can not wholly inhibit all types of reflux and are burden by 
      adverse effects. Alginate, a derivative from algae, is devoid of side effects and 
      effectively counteracts gastric material reflux forming a foaming gel in the 
      stomach. The current study enrolled 100 outpatients with LPR. Alginate treatment 
      was administered for two months. Patients underwent four visits (at baseline and 
      15, 30, and 60 days after treatment). A visual analog scale assessed the 
      perception of dysphonia, dysphagia, and cough. Alginate significantly (p<0.0001) 
      reduced all parameters. Therefore, the current study demonstrated that magnesium 
      alginate was effective and safe in LPR treatment.
CI  - Copyright 2020 Biolife Sas. www.biolifesas.org.
FAU - Ciprandi, G
AU  - Ciprandi G
AD  - Consultant allergist, Casa di Cura Villa Montallegro, Genoa, Italy.
FAU - Damiani, V
AU  - Damiani V
AD  - Medical Department, D.M.G. Italia, Pomezia, Italy.
FAU - Passali, F M
AU  - Passali FM
AD  - Department of Clinical Sciences and Translational Medicine, University of Tor 
      Vergata, Rome, Italy.
FAU - Crisanti, A
AU  - Crisanti A
AD  - Clinical Medicine Department, Regina Apostolorum Hospital, Albano Laziale, Rome, 
      Italy.
FAU - Motta, G
AU  - Motta G
AD  - ENT Clinic, University Vanvitelli, Naples, Italy.
FAU - Passali, D
AU  - Passali D
AD  - International Federation ORL Societies (IFOS) Executive Board members Rome Italy.
LA  - eng
PT  - Observational Study
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Alginates)
RN  - 0 (Proton Pump Inhibitors)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Alginates
MH  - *Deglutition Disorders
MH  - Humans
MH  - *Laryngopharyngeal Reflux/drug therapy
MH  - Magnesium
MH  - Proton Pump Inhibitors/therapeutic use
OTO - NOTNLM
OT  - cough
OT  - dysphagia
OT  - dysphonia
OT  - laryngopharyngeal reflux
OT  - magnesium alginate
EDAT- 2021/05/14 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/05/13 07:05
PHST- 2021/05/13 07:05 [entrez]
PHST- 2021/05/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - 12 [pii]
AID - 10.23812/21-1supp2-12 [doi]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1 Suppl. 2):61-64. doi: 
      10.23812/21-1supp2-12.