PMID- 33984600
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 235
DP  - 2021 Jun
TI  - Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic 
      communities in Canada.
PG  - 113754
LID - S1438-4639(21)00069-9 [pii]
LID - 10.1016/j.ijheh.2021.113754 [doi]
AB  - Polyfluoroalkyl substances and perfluoroalkyl substances (PFAS) are a family of 
      anthropogenic chemicals that are used in food packaging, waterproof clothing, and 
      firefighting foams for their water and oil resistant properties. Though levels of 
      some PFAS appear to be decreasing in Canada's south, environmental levels have 
      been increasing in the Arctic due to long-range transport. However, the 
      implications of this on human exposures in sub-Arctic and Arctic populations in 
      Canada have yet to be established. To address this data gap, human biomonitoring 
      research was completed in Old Crow, Yukon, and the Dehcho region, Northwest 
      Territories. Blood samples were collected from adults residing in seven northern 
      First Nations and were analyzed by liquid chromatography mass spectrometry. A 
      total of nine PFAS were quantified: perfluorooctanoic acid (PFOA), 
      perfluorooctane sulphonic acid (PFOS), perfluorohexane sulphonic acid (PFHxS), 
      perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and 
      perfluoroundecanoic acid (PFUdA), perfluorobutanoic acid (PFBA), 
      perfluorohexanoic acid (PFHxA), and perfluorobutane sulphonic acid (PFBS). In the 
      Dehcho (n = 124), five PFAS had a detection rate greater than 50% including PFOS, 
      PFOA, PFHxS, PFNA, and PFDA. In addition to these PFAS, PFUdA was also detected 
      in at least half of the samples collected in Old Crow (n = 54). Generally, male 
      participants had higher concentrations of PFAS compared to female participants, 
      and PFAS concentrations tended to increase with age. For most PFAS, Old Crow and 
      Dehcho levels were similar or lower to those measured in the general Canadian 
      population (as measured through the Canadian Health Measures Survey or CHMS) and 
      other First Nations populations in Canada (as measured through the First Nations 
      Biomonitoring Initiative or FNBI). The key exception to this was for PFNA which, 
      relative to the CHMS (0.51 mug/L), was approximately 1.8 times higher in Old Crow 
      (0.94 mug/L) and 2.8 times higher in Dehcho (1.42 mug/L) than observed in the 
      general Canadian population. This project provides baseline PFAS levels for 
      participating communities, improving understanding of human exposures to PFAS in 
      Canada. Future research should investigate site-specific PFNA exposure sources 
      and monitor temporal trends in these regions.
CI  - Copyright (c) 2021 Elsevier GmbH. All rights reserved.
FAU - Garcia-Barrios, Joshua
AU  - Garcia-Barrios J
AD  - School of Public Health and Health Systems, Faculty of Applied Health Sciences, 
      University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, 
      Canada.
FAU - Drysdale, Mallory
AU  - Drysdale M
AD  - School of Public Health and Health Systems, Faculty of Applied Health Sciences, 
      University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, 
      Canada.
FAU - Ratelle, Mylene
AU  - Ratelle M
AD  - School of Public Health and Health Systems, Faculty of Applied Health Sciences, 
      University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, 
      Canada.
FAU - Gaudreau, Eric
AU  - Gaudreau E
AD  - Centre de Toxicologie du Quebec (CTQ), Institut National de Sante Publique du 
      Quebec (INSPQ), Quebec, Canada.
FAU - LeBlanc, Alain
AU  - LeBlanc A
AD  - Centre de Toxicologie du Quebec (CTQ), Institut National de Sante Publique du 
      Quebec (INSPQ), Quebec, Canada.
FAU - Gamberg, Mary
AU  - Gamberg M
AD  - Gamberg Consulting, Box 11267, Whitehorse, Yukon, Y1A 6N5, Canada.
FAU - Laird, Brian D
AU  - Laird BD
AD  - School of Public Health and Health Systems, Faculty of Applied Health Sciences, 
      University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, 
      Canada. Electronic address: brian.laird@uwaterloo.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210510
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - Biological Monitoring
MH  - Biomarkers
MH  - Canada
MH  - *Environmental Pollutants
MH  - Female
MH  - *Fluorocarbons/analysis
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - Arctic
OT  - Human biomonitoring
OT  - Indigenous health
OT  - Persistent organic pollutants
OT  - Poly- and Perfluoroalkylated substances
EDAT- 2021/05/14 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/05/13 20:18
PHST- 2020/11/12 00:00 [received]
PHST- 2021/02/05 00:00 [revised]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/05/14 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/05/13 20:18 [entrez]
AID - S1438-4639(21)00069-9 [pii]
AID - 10.1016/j.ijheh.2021.113754 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2021 Jun;235:113754. doi: 10.1016/j.ijheh.2021.113754. 
      Epub 2021 May 10.