PMID- 33986851
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210516
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Jul
TI  - Clinical impact of echocardiography parameters and molecular biomarkers in heart 
      failure: Correlation of ACE2 and MCP-1 polymorphisms with echocardiography 
      parameters: A comparative study.
PG  - 686
LID - 10.3892/etm.2021.10118 [doi]
LID - 686
AB  - Heart failure is still the leading cause of hospitalization in patients over 65 
      years of age and is defined as a multifactorial pathology which involves 
      environmental factors and also genetic predispositions. The aim of the present 
      study was to evaluate a possible correlation between single nucleotide 
      polymorphisms (SNPs) of angiotensin converting enzyme 2 (ACE2) and monocyte 
      chemoattractant protein-1 (MCP-1) genes and cardiac remodeling in Caucasian 
      patients diagnosed with heart failure. Our comparative translational research 
      study included 116 patients diagnosed with heart failure and was carried out in 
      Cluj-Napoca, Romania between September 2017 and March 2019. Three SNPs, namely 
      rs4646156, rs4646174 and rs1024611, were genotyped using a Taqman real-time PCR 
      technique. Our results showed that carriers of the AA genotype for ACE2 rs4646156 
      had a significant dilatation of the left ventricle (LV) with signs of LV 
      hypertrophy (LVH), while TT carriers had a significant left atrial dilatation. 
      For ACE2 rs4646174, homozygotes for the C allele presented a dilated LV with 
      signs of LVH with statistical significance and had a tendency towards a lower 
      ejection fraction. MCP-1 rs1024611 AA variant carriers had a significant LVH in 
      the dominant model. In conclusion, our study showed a strong association between 
      echocardiographic parameters of cardiac remodeling and SNPs rs4646156, rs4646174 
      of ACE2 and rs1024611 of MCP-1.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Suciu-Petrescu, Malina
AU  - Suciu-Petrescu M
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu 
      Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
AD  - Department of Cardiology, 'Regina Maria' Hospital, 400117 Cluj-Napoca, Romania.
FAU - Truta, Anamaria
AU  - Truta A
AD  - Research Center for Functional Genomics, Biomedicine and Translational Medicine, 
      'Iuliu Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, 
      Romania.
FAU - Suciu, Mihai Domnutiu
AU  - Suciu MD
AD  - Department of Urology, Clinical Institute of Urology and Kidney Transplant, 
      'Iuliu Hatieganu' University of Medicine and Pharmacy, 400066 Cluj-Napoca, 
      Romania.
FAU - Trifa, Adrian Pavel
AU  - Trifa AP
AD  - Department of Medical Genetics, 'Iuliu Hatieganu' University of Medicine and 
      Pharmacy, 400349 Cluj-Napoca, Romania.
FAU - Petrescu, Denisa
AU  - Petrescu D
AD  - Department of Endocrinology, Emergency Clinical County Hospital Cluj, 'Iuliu 
      Hatieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
FAU - Rosianu, Horia Stefan
AU  - Rosianu HS
AD  - Department of Cardiology, 'Niculae Stancioiu' Heart Institute, 400001 
      Cluj-Napoca, Romania.
FAU - Sabin, Octavia
AU  - Sabin O
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu 
      Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
FAU - Popa, Daciana Elena
AU  - Popa DE
AD  - Department of Cardiology, 'Niculae Stancioiu' Heart Institute, 400001 
      Cluj-Napoca, Romania.
FAU - Macarie, Antonia Eugenia
AU  - Macarie AE
AD  - Department of Geriatrics-Gerontology, 'Iuliu Hatieganu' University of Medicine 
      and Pharmacy, 400139 Cluj-Napoca, Romania.
FAU - Vesa, Stefan Cristian
AU  - Vesa SC
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu 
      Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
FAU - Buzoianu, Anca Dana
AU  - Buzoianu AD
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu 
      Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
DEP - 20210428
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC8112153
OTO - NOTNLM
OT  - ACE2 polymorphism
OT  - MCP-1 polymorphism
OT  - echocardiography
OT  - heart failure
OT  - rs1024611
OT  - rs4646156
OT  - rs4646174
COIS- The authors declare that they have no competing interests.
EDAT- 2021/05/15 06:00
MHDA- 2021/05/15 06:01
PMCR- 2021/04/28
CRDT- 2021/05/14 06:59
PHST- 2021/02/05 00:00 [received]
PHST- 2021/03/08 00:00 [accepted]
PHST- 2021/05/14 06:59 [entrez]
PHST- 2021/05/15 06:00 [pubmed]
PHST- 2021/05/15 06:01 [medline]
PHST- 2021/04/28 00:00 [pmc-release]
AID - ETM-0-0-10118 [pii]
AID - 10.3892/etm.2021.10118 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 Jul;22(1):686. doi: 10.3892/etm.2021.10118. Epub 2021 Apr 28.