PMID- 33987258
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 9
IP  - 7
DP  - 2021 Apr
TI  - Association between renal function and retinal neurodegeneration in Chinese 
      patients with type 2 diabetes mellitus.
PG  - 560
LID - 10.21037/atm-20-6957 [doi]
LID - 560
AB  - BACKGROUND: Chronic kidney disease (CKD) and diabetic retinopathy (DR) are two 
      serious complications of diabetes. However, the association between retinal 
      neurodegeneration in DR and renal function decline is still unclear. Our 
      objective was to evaluate the association by measure estimated glomerular 
      filtration rate (eGFR), macular ganglion cell-inner plexiform layer (GC-IPL), and 
      ganglion cell complex (GCC) thickness in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: We analyzed the baseline data of the Guangzhou Diabetic Eye 
      Study. T2DM patients from communities in Guangzhou were enrolled and all 
      participants went through ophthalmic and general examinations. The thickness of 
      the macular GC-IPL and GCC in their right eyes were measured by swept-source 
      optical coherence tomography. CKD was defined as eGFR <60 mL/min/1.73 m(2). 
      RESULTS: One thousand three hundred and nine patients were included (mean age 
      64.4+/-7.6 years, 59.1% female), and fifty-eight (4.4%) of them had CKD. Average 
      macular GC-IPL thickness was significantly thinner in CKD patients (96.5+/-9.1 microm) 
      than non-CKD patients (101.3+/-9.2 microm) (P<0.01). Average macular GCC thickness was 
      also significantly thinner in CKD patients (123.5+/-13.2 microm) than non-CKD patients 
      (129.9+/-12.8 microm) (P<0.01). The significant thinning of macular GC-IPL and GCC 
      thickness presented in every gird in the macula (all, P<0.05) except for central 
      grid (P>/=0.05). In the patients without DR, the eGFR was linearly correlated with 
      the average macular GC-IPL thickness [beta=0.07 (95% CI, 0.02-0.12), P<0.01] and GCC 
      thickness [beta=0.09 (95% CI, 0.03-0.16), P<0.01] after adjustment for age, sex, 
      axial length, intraocular pressure (IOP) and combination of hypertension. 
      However, no linear correlation was found between eGFR and macular GC-IPL or GCC 
      thickness in DR patients. CONCLUSIONS: Renal function decrease is associated with 
      the thinning of the macular GC-IPL and GCC in T2DM patients, suggesting the 
      potential value of ganglion cell lose to detect early function decline in the 
      kidney in diabetic patients, especially in patients without DR.
CI  - 2021 Annals of Translational Medicine. All rights reserved.
FAU - Gong, Xia
AU  - Gong X
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Li, Wangting
AU  - Li W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Jin, Ling
AU  - Jin L
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Wang, Lanhua
AU  - Wang L
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Meng, Jie
AU  - Meng J
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Xiong, Kun
AU  - Xiong K
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Li, Yuting
AU  - Li Y
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Han, Xiao
AU  - Han X
AD  - The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
FAU - Liang, Xiaoling
AU  - Liang X
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Huang, Wenyong
AU  - Huang W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC8105784
OTO - NOTNLM
OT  - Diabetes
OT  - neurodegeneration
OT  - optical coherent tomography
OT  - renal function
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-20-6957). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/05/15 06:00
MHDA- 2021/05/15 06:01
PMCR- 2021/04/01
CRDT- 2021/05/14 07:02
PHST- 2021/05/14 07:02 [entrez]
PHST- 2021/05/15 06:00 [pubmed]
PHST- 2021/05/15 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - atm-09-07-560 [pii]
AID - 10.21037/atm-20-6957 [doi]
PST - ppublish
SO  - Ann Transl Med. 2021 Apr;9(7):560. doi: 10.21037/atm-20-6957.