PMID- 33987370
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 9
IP  - 8
DP  - 2021 Apr
TI  - Large HDL(2) combined with inflammatory factors as superior predictors for 
      coronary artery disease than small HDL(3).
PG  - 672
LID - 10.21037/atm-21-948 [doi]
LID - 672
AB  - BACKGROUND: This study investigated whether combinations of high-density 
      lipoprotein (HDL) subfractions and inflammatory markers would add value to 
      coronary artery disease (CAD) prediction. METHODS: Non-CAD subjects (n=245) were 
      stratified into low/moderate/high-Framingham risk (L/M/H-FR) groups and 180 CAD 
      patients were enrolled. Levels of HDL-C, HDL(2), HDL(3), monocyte chemoattractant 
      protein-1 (MCP-1), and high-sensitivity C-reactive protein (hsCRP) were measured. 
      Multivariable logistic models for CAD were estimated with a single parameter or 
      all parameters together after adjustment for conventional risk factors (CRFs), 
      and Z statistics, net reclassification improvement (NRI), and integrated 
      discrimination improvement (IDI) were used to compare discrimination among 
      different models. RESULTS: The results show that HDL-C, HDL(2,) and HDL(3) 
      gradually decreased, while MCP-1 and hsCRP gradually increased from L/M/H-FR to 
      the CAD group. When applying a single factor in the CRFs-adjusted models, HDL-C 
      (OR 0.011, 95% CI, 0.002-0.071, P<0.05) and HDL(2) (OR 0.000072, 95% CI, 
      0.000001-0.004, P<0.05), but not HDL(3), were significantly related to CAD risk. 
      Only HDL(2) (OR 0.000072, 95% CI, 0.000001-0.004, P<0.001) remained significant 
      when applying all HDL parameters. In the model including all HDL and inflammatory 
      parameters, HDL(2) (OR 0.001, 95% CI, 0.000027-0.051), MCP-1 (OR 1.066, 95% CI, 
      1.039-1.094), and hsCRP (OR 1.130, 95% CI, 1.041-1.227) showed significant 
      differences (all P<0.05). This combined model showed improved discrimination over 
      the models with a single factor (P<0.05) or all HDL parameters (Z=3.299, NRI 
      =0.179, IDI =0.081, P<0.001). CONCLUSIONS: Large HDL(2) is superior to small 
      HDL(3) in the inverse association with CAD. The combination of HDL(2), MCP-1, and 
      hsCRP with CRFs provides an optimal prediction for CAD.
CI  - 2021 Annals of Translational Medicine. All rights reserved.
FAU - Wu, Xiaoying
AU  - Wu X
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - He, Zhijian
AU  - He Z
AD  - Cardiovascular Medicine Department, The First Affiliated Hospital/School of 
      Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Sun, Runlu
AU  - Sun R
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Xie, Xiangkun
AU  - Xie X
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Chen, Qingqun
AU  - Chen Q
AD  - Cardiovascular Medicine Department, Qingyuan People's Hospital, Qingyuan, China.
FAU - Wang, Junjie
AU  - Wang J
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Bao, Jinlan
AU  - Bao J
AD  - Comprehensive Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Huang, Jingjing
AU  - Huang J
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Jiang, Yuan
AU  - Jiang Y
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Zhang, Yuling
AU  - Zhang Y
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Wang, Jingfeng
AU  - Wang J
AD  - Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC8106016
OTO - NOTNLM
OT  - Coronary artery disease (CAD)
OT  - combined prediction
OT  - high-density lipoprotein subfractions (HDL subfractions)
OT  - high-sensitivity C-reactive protein (hsCRP)
OT  - monocyte chemoattractant factor-1
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-21-948). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/05/15 06:00
MHDA- 2021/05/15 06:01
PMCR- 2021/04/01
CRDT- 2021/05/14 07:03
PHST- 2021/05/14 07:03 [entrez]
PHST- 2021/05/15 06:00 [pubmed]
PHST- 2021/05/15 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - atm-09-08-672 [pii]
AID - 10.21037/atm-21-948 [doi]
PST - ppublish
SO  - Ann Transl Med. 2021 Apr;9(8):672. doi: 10.21037/atm-21-948.