PMID- 33988002
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2287-4208 (Print)
IS  - 2287-4690 (Electronic)
IS  - 2287-4208 (Linking)
VI  - 40
IP  - 2
DP  - 2022 Apr
TI  - Efficacy and Safety of Penile Girth Enhancement Using Hyaluronic Acid Filler and 
      the Clinical Impact on Ejaculation: A Multi-Center, Patient/Evaluator-Blinded, 
      Randomized Active-Controlled Trial.
PG  - 299-307
LID - 10.5534/wjmh.210007 [doi]
AB  - PURPOSE: We aimed to evaluate the efficacy and safety of penile girth enhancement 
      (PGE) using hyaluronic acid (HA) filler with different physical properties from 
      previous studies. Additionally, we evaluated the clinical impact on ejaculation 
      after PGE. MATERIALS AND METHODS: This was a prospective, 
      patient/evaluator-blinded, randomized, active-controlled, multicenter trial. 
      Patients recruited between December 2017 and March 2018 were randomly assigned to 
      the HA filler or control group (polylactic acid [PLA] filler). Penile girth, 
      satisfaction level, Premature Ejaculation Profile (PEP), and self-estimated 
      intravaginal ejaculation latency time (IELT) were assessed at baseline and at 24 
      weeks post-injection. RESULTS: Sixty-four subjects (32 in each group) completed 
      the trial. The mean increase in girth was 22.74+/-12.60 mm and 20.23+/-8.73 mm in the 
      HA and control groups, respectively. Satisfaction level regarding penile 
      appearance and sexual life significantly increased in both groups. There was no 
      statistically significant difference between the groups in terms of increase in 
      penile girth or change in satisfaction level. Both groups showed significant 
      improvements in PEP index scores. Self-estimated IELT also significantly 
      increased in the HA group (from 5.36+/-3.51 to 7.86+/-4.73 minutes, p=0.0001) and 
      control group (from 5.23+/-3.55 to 6.43+/-4.22 minutes, p=0.021). No serious adverse 
      events (AEs) were reported. CONCLUSIONS: PGE with HA and PLA fillers resulted in 
      significant enhancement of girth without serious AEs with no significant 
      differences. Furthermore, PGE using filler improved clinical symptoms related to 
      ejaculation.
CI  - Copyright (c) 2022 Korean Society for Sexual Medicine and Andrology.
FAU - Ahn, Sun Tae
AU  - Ahn ST
AUID- ORCID: 0000-0003-1233-5951
AD  - Department of Urology, Korea University Guro Hospital, Korea University College 
      of Medicine, Seoul, Korea.
FAU - Shim, Ji Sung
AU  - Shim JS
AUID- ORCID: 0000-0002-6745-1776
AD  - Department of Urology, Korea University Anam Hospital, Korea University College 
      of Medicine, Seoul, Korea.
FAU - Bae, Woong Jin
AU  - Bae WJ
AUID- ORCID: 0000-0001-7703-1161
AD  - Department of Urology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Kim, Sae Woong
AU  - Kim SW
AUID- ORCID: 0000-0002-9127-9400
AD  - Department of Urology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Kim, Je Jong
AU  - Kim JJ
AUID- ORCID: 0000-0002-1195-9845
AD  - Department of Urology, Korea University Anam Hospital, Korea University College 
      of Medicine, Seoul, Korea.
FAU - Moon, Du Geon
AU  - Moon DG
AUID- ORCID: 0000-0002-9031-9845
AD  - Department of Urology, Korea University Guro Hospital, Korea University College 
      of Medicine, Seoul, Korea. dgmoon@korea.ac.kr.
LA  - eng
GR  - Humedix, Co., Ltd./Korea
PT  - Journal Article
DEP - 20210507
PL  - Korea (South)
TA  - World J Mens Health
JT  - The world journal of men's health
JID - 101596899
PMC - PMC8987147
OTO - NOTNLM
OT  - Ejaculation
OT  - Filler
OT  - Girth enhancement
OT  - Hyaluronic acid
OT  - Penis
COIS- The authors have nothing to disclose.
EDAT- 2021/05/15 06:00
MHDA- 2021/05/15 06:01
PMCR- 2022/04/01
CRDT- 2021/05/14 07:24
PHST- 2021/01/25 00:00 [received]
PHST- 2021/03/31 00:00 [revised]
PHST- 2021/03/31 00:00 [accepted]
PHST- 2021/05/15 06:00 [pubmed]
PHST- 2021/05/15 06:01 [medline]
PHST- 2021/05/14 07:24 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 39.e23 [pii]
AID - 10.5534/wjmh.210007 [doi]
PST - ppublish
SO  - World J Mens Health. 2022 Apr;40(2):299-307. doi: 10.5534/wjmh.210007. Epub 2021 
      May 7.