PMID- 33988638
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20211123
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 12
DP  - 2021 Jun 21
TI  - Carboxymethyl konjac glucomannan coating on multilayered emulsions for improved 
      bioavailability and targeted delivery of curcumin.
PG  - 5429-5439
LID - 10.1039/d0fo03390a [doi]
AB  - Curcumin was entrapped in multilayered emulsions to increase its stability and 
      bioavailability. Curcumin emulsion stabilized by whey protein isolate (WPI) was 
      coated with chitosan (CHI) or carboxymethyl konjac glucomannan (CMKGM) alone to 
      form secondary emulsions and their combination in sequence to form the tertiary 
      emulsion, in which, the polyelectrolyte concentrations were 1.0% WPI for the 
      primary emulsion, 0.4% CMKGM for the secondary emulsion -CMKGM, 0.2% CHI for the 
      secondary emulsion -CHI, and 0.1% CMKGM for the tertiary emulsion. The 
      characteristics of the emulsions, including their particle size, zeta potential, 
      microstructure, creaming stability, and biopolymer distribution, were 
      investigated and their colon-targeted delivery potential was evaluated through 
      both in vitro and in vivo studies as well. The curcumin-loaded secondary and 
      tertiary emulsions were stable with a narrow size distribution and were generated 
      by layer-by-layer assembly according to confocal laser scanning microscope 
      observation. When CMKGM was located at the outermost layer, the corresponding 
      secondary and tertiary emulsions showed a greatly reduced release of curcumin in 
      the simulated gastric fluid, but exhibited increased release in the 
      beta-mannanase-containing simulated colonic fluid. In vivo evaluation in mice 
      demonstrated that the bioavailability of curcumin in the CMKGM-coated secondary 
      and tertiary emulsions was increased by about 4 folds compared with that of free 
      curcumin and curcumin could be released in a sustainable manner. These results 
      demonstrated that multilayered emulsions coated with CMKGM could promote curcumin 
      absorption in the gastrointestinal tract and hence is a promising colon-targeted 
      delivery system for curcumin.
FAU - Wang, Lu-Hui
AU  - Wang LH
AD  - College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 
      266109, PR China. hgqfood@qau.edu.cn.
FAU - Xiao, Jun-Xia
AU  - Xiao JX
FAU - Li, Xiao-Dan
AU  - Li XD
FAU - Huang, Guo-Qing
AU  - Huang GQ
LA  - eng
PT  - Journal Article
DEP - 20210514
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsions)
RN  - 0 (Mannans)
RN  - 0 (carboxymethyl konjac glucomannan)
RN  - 9012-76-4 (Chitosan)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - Chitosan/chemistry
MH  - Colon
MH  - Curcumin/*chemistry
MH  - Drug Carriers/*chemistry
MH  - Drug Delivery Systems
MH  - Emulsions/*chemistry
MH  - Mannans/*chemistry
MH  - Mice
MH  - Particle Size
MH  - Pharmacokinetics
EDAT- 2021/05/15 06:00
MHDA- 2021/11/24 06:00
CRDT- 2021/05/14 12:22
PHST- 2021/05/15 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2021/05/14 12:22 [entrez]
AID - 10.1039/d0fo03390a [doi]
PST - ppublish
SO  - Food Funct. 2021 Jun 21;12(12):5429-5439. doi: 10.1039/d0fo03390a. Epub 2021 May 
      14.