PMID- 3398871
OWN - NLM
STAT- MEDLINE
DCOM- 19880830
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 208
IP  - 3-4
DP  - 1988 Jul
TI  - 1,6-Dinitropyrene causes spindle disturbances and chromosomal damage in V79 
      Chinese hamster cells.
PG  - 213-8
AB  - We have investigated the cytogenetic effect of 1,6-dinitropyrene (1,6-DNP) in 
      Chinese hamster V79 cells. The chemical caused a dose-dependent increase in the 
      incidence of initial and full C-mitoses, polyploid mitoses, ana-telophases with 
      lagging chromosomes, non-disjunction and multipolar configurations, in a range of 
      0.05-5 microM. These findings indicate that 1,6-DNP interferes with the 
      functioning of the spindle apparatus in V79 cells. Early signs of spindle 
      disturbances were seen at 1,6-DNP concentrations which only moderately reduced 
      cell growth and division. Analysis of structural chromosomal aberrations revealed 
      the appearance of chromatid-type aberrations with open breaks and exchanges 
      accompanied by gaps. The results indicate that 1,6-DNP is both a 
      spindle-disturbing and a clastogenic agent in V79 cells.
FAU - Bauchinger, M
AU  - Bauchinger M
AD  - Institut fur Strahlenbiologie, Umweltforschung Munich, Neuherberg, F.R.G.
FAU - Schmid, E
AU  - Schmid E
FAU - Wiebel, F J
AU  - Wiebel FJ
FAU - Roscher, E
AU  - Roscher E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Mutagens)
RN  - 0 (Pyrenes)
RN  - 66Q2ZUF83N (1,6-dinitropyrene)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects
MH  - Cell Line
MH  - *Chromosome Aberrations
MH  - Cricetinae
MH  - DNA Damage
MH  - Dose-Response Relationship, Drug
MH  - Mitosis/drug effects
MH  - Mitotic Index/drug effects
MH  - Mutagens
MH  - Pyrenes/*toxicity
MH  - Spindle Apparatus/*drug effects
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 0165-7992(88)90063-2 [pii]
AID - 10.1016/0165-7992(88)90063-2 [doi]
PST - ppublish
SO  - Mutat Res. 1988 Jul;208(3-4):213-8. doi: 10.1016/0165-7992(88)90063-2.