PMID- 33991256
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220107
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 188
IP  - 6
DP  - 2021 May 15
TI  - Lithium cobalt phosphate electrode for the simultaneous determination of ascorbic 
      acid, dopamine, and serum uric acid by differential pulse voltammetry.
PG  - 190
LID - 10.1007/s00604-021-04839-5 [doi]
AB  - Lithium cobalt phosphate (LCP) was prepared and modified on the surface of glassy 
      carbon electrode (GCE) to fabricate the electrochemical sensor (LCP/GCE) for the 
      simultaneous determination of ascorbic acid (AA), dopamine (DA), and serum uric 
      acid (UA). The homogenous incorporation of carbon improved the conductivity of 
      LCP. Benefiting from the small particle size distribution, LCP/GCE has a large 
      active surface and responds to AA, DA, and UA sensitively and rapidly. For the 
      simultaneous detection with differential pulse voltammetry the anodic peaks of 
      AA, DA, and UA were well-separated and appeared at ~0 V, ~0.19 V, and ~ 0.33 V 
      (vs. Ag/AgCl), respectively. The linear responses toward AA, DA, and UA were in 
      the range 10 muM-8.0 mM, 10 nM-10 muM, and 0.020 muM-25 muM; the detection limits 
      were estimated to be 8.10 muM, 7.50 nM, and 22.7 nM (S/N = 3), respectively. The 
      excellent selectivity and reproducibility of LCP/GCE enable serum UA to be 
      detected without the interference of AA and DA. The recoveries of DA and AA in 
      the serum sample were in the range 95 to 111%. The results indicate that LCP has 
      the potential to be developed as the sensing devices to be applied to in vitro 
      diagnosis. The lithium-ion battery cathodic material, LCP with the excellent 
      adsorption and catalytic behavior, was utilized to fabricate the electrochemical 
      sensor for the sensitive and simultaneous detection of AA, DA, and UA, which 
      achieved the low detection limits and the wide concentration ranges. LCP/GCE can 
      be used for the quantitative detection of serum UA without the interference of DA 
      and AA. In addition, the recoveries of DA and AA in human serum were 
      satisfactory, which illustrate the reliability of LCP/GCE to be applied to in 
      vitro diagnosis.
FAU - Xu, Yanxue
AU  - Xu Y
AD  - Institute of Advanced Study, Chengdu University, No. 2025, Chengluo Avenue, 
      Chengdu, People's Republic of China.
FAU - Meng, Zirui
AU  - Meng Z
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 
      37, Guoxue Lane, Chengdu, People's Republic of China.
FAU - Meng, Yan
AU  - Meng Y
AD  - College of Chemical Engineering, Sichuan University, No. 29 Wangjiang Road, 
      Chengdu, People's Republic of China.
FAU - Li, Xiaoqin
AU  - Li X
AD  - Institute of Advanced Study, Chengdu University, No. 2025, Chengluo Avenue, 
      Chengdu, People's Republic of China.
FAU - Xiao, Dan
AU  - Xiao D
AD  - Institute of Advanced Study, Chengdu University, No. 2025, Chengluo Avenue, 
      Chengdu, People's Republic of China. xiaodan@scu.edu.cn.
AD  - College of Chemical Engineering, Sichuan University, No. 29 Wangjiang Road, 
      Chengdu, People's Republic of China. xiaodan@scu.edu.cn.
LA  - eng
GR  - 81927809/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210515
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Phosphates)
RN  - 268B43MJ25 (Uric Acid)
RN  - 3G0H8C9362 (Cobalt)
RN  - 7440-44-0 (Carbon)
RN  - 9FN79X2M3F (Lithium)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Ascorbic Acid/*blood/chemistry
MH  - Carbon/chemistry
MH  - Cobalt/chemistry
MH  - Dopamine/*blood/chemistry
MH  - Electrochemical Techniques/instrumentation/methods
MH  - Electrodes
MH  - Humans
MH  - Limit of Detection
MH  - Lithium/chemistry
MH  - Oxidation-Reduction
MH  - Phosphates/chemistry
MH  - Reproducibility of Results
MH  - Uric Acid/*blood/chemistry
OTO - NOTNLM
OT  - Dopamine
OT  - Electrochemical sensor
OT  - Lithium cobalt phosphate
OT  - Serum uric acid
EDAT- 2021/05/16 06:00
MHDA- 2022/01/08 06:00
CRDT- 2021/05/15 12:06
PHST- 2021/01/17 00:00 [received]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/05/15 12:06 [entrez]
PHST- 2021/05/16 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
AID - 10.1007/s00604-021-04839-5 [pii]
AID - 10.1007/s00604-021-04839-5 [doi]
PST - epublish
SO  - Mikrochim Acta. 2021 May 15;188(6):190. doi: 10.1007/s00604-021-04839-5.