PMID- 33991311
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 0975-0711 (Electronic)
IS  - 0254-8860 (Linking)
VI  - 40
IP  - 6
DP  - 2021 Dec
TI  - Baveno criteria perform better than expanded Baveno and Rete Sicilia Selezione 
      Terapia-Hepatitis C virus criteria for predicting varices needing treatment.
PG  - 590-597
LID - 10.1007/s12664-020-01141-9 [doi]
AB  - BACKGROUND AND AIMS: Endoscopy is the gold standard for the detection and staging 
      of varices. Baveno, expanded Baveno, and Rete Sicilia Selezione Terapia-hepatitis 
      C virus (RESIST-HCV) criteria predict varices non-invasively in patients with 
      cirrhosis. We assessed the performance of these criteria for predicting varices 
      needing treatment (VNT). METHODS: Consecutive patients with compensated cirrhosis 
      due to viral etiologies evaluated between January 2014 and May 2017 were included 
      in this retrospective analysis of a prospectively maintained database. VNTs were 
      defined as either large varies or small varices with red color signs on 
      endoscopy. Performance characteristics to predict VNTs were estimated for the 
      three criteria and spared endoscopy rate (SER) and missed VNT rates were 
      determined. RESULTS: Two hundred and ninety-five treatment-naive cirrhosis 
      patients, etiology hepatitis B (n = 154) or hepatitis C (n = 141), mean age 
      43.1 +/- 13.2 years, 127 (43.1%) males were included. The median liver stiffness 
      measurement (LSM) and platelet counts were 19.7 (interquartile range [IQR]: 
      14.8-28.8) kPa and 119 (IQR: 80-160) x 10(3)/mm(3), respectively. The SER and 
      missed VNT rates were as follows-for Baveno criteria: 18.3% and 6.2%; expanded 
      Baveno: 35.3% and 29.2%; and for RESIST-HCV criteria: 37.3% and 22.9%. The 
      sensitivity, specificity, positive predictive value, and negative predictive 
      value were 93.7%, 21.9%, 18.9%, and 94.7% for Baveno criteria; 70.8%, 42.3%, 
      19.3%, and 88.1% for expanded Baveno; and 77.1%, 44.5%, 21.3%, and 90.9% for 
      RESIST-HCV criteria, respectively. CONCLUSION: Baveno criteria are useful to 
      avoid screening endoscopies in patients with cirrhosis of viral etiologies. In 
      contrast, although expanded Baveno criteria and RESIST-HCV criteria spare more 
      endoscopies, a high missed VNT rate limits their applicability.
CI  - (c) 2020. Indian Society of Gastroenterology.
FAU - Agarwal, Ashish
AU  - Agarwal A
AD  - Department of Gastroenterology and Human Nutrition Unit, All India Institute of 
      Medical Sciences, New Delhi, 110 029, India.
FAU - Pathak, Piyush
AU  - Pathak P
AD  - Department of Gastroenterology and Human Nutrition Unit, All India Institute of 
      Medical Sciences, New Delhi, 110 029, India.
FAU - Gupta, Swatantra
AU  - Gupta S
AD  - Department of Gastroenterology and Hepatology, Dr. Rajendra Prasad Medical 
      College, Kangra, Tanda 176 001, India.
FAU - Kumar, Ramesh
AU  - Kumar R
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, Patna, 
      801 507, India.
FAU - Shalimar
AU  - Shalimar
AUID- ORCID: 0000-0003-1247-437X
AD  - Department of Gastroenterology and Human Nutrition Unit, All India Institute of 
      Medical Sciences, New Delhi, 110 029, India. drshalimar@yahoo.com.
LA  - eng
GR  - 1189/19/RS/4542/Physicians Research Foundation/
PT  - Journal Article
DEP - 20210515
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
SB  - IM
CIN - Indian J Gastroenterol. 2021 Dec;40(6):551-555. PMID: 35076892
MH  - Adult
MH  - *Elasticity Imaging Techniques
MH  - *Esophageal and Gastric Varices/diagnosis/etiology/therapy
MH  - Female
MH  - Hepacivirus
MH  - *Hepatitis C/complications/diagnosis
MH  - Humans
MH  - Liver Cirrhosis/complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Varicose Veins
OTO - NOTNLM
OT  - Albumin
OT  - Bilirubin
OT  - Bleeding
OT  - Cirrhosis
OT  - Endoscopy
OT  - INR
OT  - Liver
OT  - Non-invasive
OT  - Platelet count
OT  - RESIST-HCV criteria
OT  - Transient elastography
EDAT- 2021/05/16 06:00
MHDA- 2022/05/03 06:00
CRDT- 2021/05/15 12:08
PHST- 2020/10/05 00:00 [received]
PHST- 2020/12/15 00:00 [accepted]
PHST- 2021/05/16 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2021/05/15 12:08 [entrez]
AID - 10.1007/s12664-020-01141-9 [pii]
AID - 10.1007/s12664-020-01141-9 [doi]
PST - ppublish
SO  - Indian J Gastroenterol. 2021 Dec;40(6):590-597. doi: 10.1007/s12664-020-01141-9. 
      Epub 2021 May 15.