PMID- 33991459
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20221005
IS  - 2328-9503 (Electronic)
IS  - 2328-9503 (Linking)
VI  - 8
IP  - 7
DP  - 2021 Jul
TI  - No strong HLA association with MOG antibody disease in the UK population.
PG  - 1502-1507
LID - 10.1002/acn3.51378 [doi]
AB  - Improvements in assays for detecting serum antibodies against myelin 
      oligodendrocyte glycoprotein (MOG) have led to the appreciation of 
      MOG-antibody-associated disease (MOGAD) as a novel disorder. However, much 
      remains unknown about its etiology. We performed human leukocyte antigen (HLA) 
      analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA 
      class II associations were observed, thus questioning the mechanism of anti-MOG 
      antibody generation. A weak protective association of HLA-C*03:04 was observed 
      (OR = 0.26, 95% CI = 0.10-0.71, p(c)  = 0.013), suggesting a need for continued 
      efforts to better understand MOGAD genetics and pathophysiology.
CI  - (c) 2021 The Authors. Annals of Clinical and Translational Neurology published by 
      Wiley Periodicals LLC on behalf of American Neurological Association.
FAU - Grant-Peters, Melissa
AU  - Grant-Peters M
AD  - Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University 
      of Oxford, Oxford, UK.
FAU - Passos, Giordani Rodrigues Dos
AU  - Passos GRD
AD  - Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.
AD  - Brain Institute and Department of Neurology, Pontifical Catholic University of 
      Rio Grande do Sul Porto Alegre, Brazil.
FAU - Yeung, Hing-Yuen
AU  - Yeung HY
AD  - Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University 
      of Oxford, Oxford, UK.
FAU - Jacob, Anu
AU  - Jacob A
AD  - Walton Centre, NHS Foundation Trust, Liverpool, UK.
FAU - Huda, Saif
AU  - Huda S
AD  - Walton Centre, NHS Foundation Trust, Liverpool, UK.
FAU - Leite, Maria Isabel
AU  - Leite MI
AD  - Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.
FAU - Dendrou, Calliope A
AU  - Dendrou CA
AUID- ORCID: 0000-0003-1179-4021
AD  - Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University 
      of Oxford, Oxford, UK.
FAU - Palace, Jacqueline
AU  - Palace J
AD  - Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 204290/Z/16/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210515
PL  - United States
TA  - Ann Clin Transl Neurol
JT  - Annals of clinical and translational neurology
JID - 101623278
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Female
MH  - Genetic Association Studies/*methods
MH  - HLA Antigens/*blood/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelin-Oligodendrocyte Glycoprotein/*blood/genetics
MH  - Neuromyelitis Optica/*blood/*epidemiology/genetics
MH  - United Kingdom/epidemiology
MH  - Young Adult
PMC - PMC8283171
COIS- Prof Palace reports grants and personal fees from Merck Serono, Chugai, 
      MedImmune, Alexion, and ABIDE, and personal fees from Teva, Roche, MEDDAY, 
      ARGENX, Mitsubishi, UCB, and Viela Bio, outside the submitted work. In addition, 
      Prof Palace has a patent Isis: Diagnosing Multiple Sclerosis issued, and a patent 
      Know-how from the Numares Collaboration pending. Dr. dos Passos reports a 
      scholarship from ECTRIMS, a scholarship from the World Federation of Neurology, 
      grants and personal fees from Novartis and Biogen, personal fees and 
      non-financial support from Roche and Merck, personal fees from Bayer, and 
      non-financial support from Teva and Sanofi-Genzyme, outside the submitted work. 
      Dr. Leite is funded by the NHS National Specialized Commissioning Group for 
      Neuromyelitis optica, UK and by the NIHR Oxford Biomedical Research Centre, UK. 
      She has been awarded research grants from The Myaware and University of Oxford. 
      She has received speaker honoraria or travel grants from Biogen Idec, Novartis, 
      and the Guthy-Jackson Charitable Foundation. Dr Leite serves on scientific or 
      educational advisory boards for UCB, Argenx, and Viela Bio. The other authors 
      declare no conflicts of interest.
EDAT- 2021/05/16 06:00
MHDA- 2022/01/19 06:00
PMCR- 2021/05/15
CRDT- 2021/05/15 17:06
PHST- 2021/04/12 00:00 [revised]
PHST- 2021/01/13 00:00 [received]
PHST- 2021/04/22 00:00 [accepted]
PHST- 2021/05/16 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
PHST- 2021/05/15 17:06 [entrez]
PHST- 2021/05/15 00:00 [pmc-release]
AID - ACN351378 [pii]
AID - 10.1002/acn3.51378 [doi]
PST - ppublish
SO  - Ann Clin Transl Neurol. 2021 Jul;8(7):1502-1507. doi: 10.1002/acn3.51378. Epub 
      2021 May 15.