PMID- 33992754
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1873-3441 (Electronic)
IS  - 0939-6411 (Linking)
VI  - 165
DP  - 2021 Aug
TI  - Design of experiments (DoE) to develop and to optimize nanoparticles as drug 
      delivery systems.
PG  - 127-148
LID - S0939-6411(21)00135-1 [pii]
LID - 10.1016/j.ejpb.2021.05.011 [doi]
AB  - Nanotechnology has been widely applied to develop drug delivery systems to 
      improve therapeutic performance. The effectiveness of these systems is 
      intrinsically related to their physicochemical properties, so their biological 
      responses are highly susceptible to factors such as the type and quantity of each 
      material that is employed in their synthesis and to the method that is used to 
      produce them. In this context, quality-oriented manufacturing of nanoparticles 
      has been an important strategy to understand and to optimize the factors involved 
      in their production. For this purpose, Design of Experiment (DoE) tools have been 
      applied to obtain enough knowledge about the process and hence achieve 
      high-quality products. This review aims to set up the bases to implement DoE as a 
      strategy to improve the manufacture of nanocarriers and to discuss the main 
      factors involved in the production of the most common nanocarriers employed in 
      the pharmaceutical field.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Tavares Luiz, Marcela
AU  - Tavares Luiz M
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, 
      Ribeirao Preto, SP, Brazil.
FAU - Santos Rosa Viegas, Juliana
AU  - Santos Rosa Viegas J
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, 
      Ribeirao Preto, SP, Brazil.
FAU - Palma Abriata, Juliana
AU  - Palma Abriata J
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, 
      Ribeirao Preto, SP, Brazil.
FAU - Viegas, Felipe
AU  - Viegas F
AD  - Department of Computer Science, Federal University of Minas Gerais, Belo 
      Horizonte, MG, Brazil.
FAU - Testa Moura de Carvalho Vicentini, Fabiana
AU  - Testa Moura de Carvalho Vicentini F
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, 
      Ribeirao Preto, SP, Brazil.
FAU - Lopes Badra Bentley, Maria Vitoria
AU  - Lopes Badra Bentley MV
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, 
      Ribeirao Preto, SP, Brazil.
FAU - Chorilli, Marlus
AU  - Chorilli M
AD  - School of Pharmaceutical Sciences, Sao Paulo State University, Araraquara, SP, 
      Brazil.
FAU - Maldonado Marchetti, Juliana
AU  - Maldonado Marchetti J
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, 
      Ribeirao Preto, SP, Brazil.
FAU - Tapia-Blacido, Delia Rita
AU  - Tapia-Blacido DR
AD  - Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirao 
      Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210513
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Chemistry, Pharmaceutical
MH  - Drug Carriers/*chemistry
MH  - Drug Compounding/*methods
MH  - Nanomedicine/methods
MH  - Nanoparticles/*chemistry
MH  - *Research Design
OTO - NOTNLM
OT  - Box-Behnken Design
OT  - Central Composite Design
OT  - Fractional Factorial Design
OT  - Full Factorial Design
OT  - Nanomedicine
OT  - Nanotechnology
OT  - Plackett-Burman Design
OT  - Quality by Design
OT  - Response Surface Methodology
EDAT- 2021/05/17 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/05/16 20:38
PHST- 2020/07/03 00:00 [received]
PHST- 2021/04/05 00:00 [revised]
PHST- 2021/05/08 00:00 [accepted]
PHST- 2021/05/17 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/16 20:38 [entrez]
AID - S0939-6411(21)00135-1 [pii]
AID - 10.1016/j.ejpb.2021.05.011 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 2021 Aug;165:127-148. doi: 10.1016/j.ejpb.2021.05.011. Epub 
      2021 May 13.