PMID- 33992947
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20210614
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 787
DP  - 2021 Sep 15
TI  - Serum concentrations of per-/polyfluoroalkyl substances and risk of type 2 
      diabetes: A case-control study.
PG  - 147476
LID - S0048-9697(21)02547-X [pii]
LID - 10.1016/j.scitotenv.2021.147476 [doi]
AB  - Per-/polyfluoroalkyl substances (PFASs), as a group of synthetic chemicals, have 
      been extensively detected in human samples. Recently, epidemiological 
      investigations have reported relationships between exposure to PFASs with risk of 
      type 2 diabetes mellitus (T2DM), but with contradictory results. In this study, a 
      case-control study was conducted to explore associations between serum PFASs and 
      T2DM risk among 252 T2DM cases and 252 controls, who were both diagnosed 
      according to fasting glucose and glycosylated hemoglobin levels. Besides, 
      dose-response relationships were analyzed to clarify effects of PFAS exposure on 
      T2DM risk at different exposure levels. Multivariable logistic regression models 
      showed that compared to the lowest tertiles, elevated odds of T2DM risk were 
      observed in the middle tertiles of perfluorohexane sulfonic acid (PFHxS) [odds 
      ratio (OR): 4.09; 95% confidence interval (CI): 2.23, 7.50; p < 0.01] and 
      perfluorohexane sulfonic acid (PFHpA) (OR: 1.87; 95% CI: 1.06, 3.29; p = 0.03), 
      but not in the highest tertiles, and the restricted cubic spline regression 
      models presented inverted U-shaped dose-response relationships for exposure to 
      PFHxS and PFHpA with T2DM risk, indicating non-monotonic dose-response effect and 
      low-dose effect. Most other PFASs were inversely associated with risk of T2DM, 
      especially at higher exposure levels. Our findings suggested that there are 
      associations between exposure to PFASs and risk of T2DM. Further mechanism 
      research is worthy to be conducted to elucidate the mode of action of different 
      PFASs on T2DM at different exposure levels.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Duan, Yishuang
AU  - Duan Y
AD  - Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic 
      Substances, Institute of Environment and Health, Jianghan University, Wuhan, 
      China; Ministry of Education Key Laboratory of Pollution Processes and 
      Environmental Criteria, College of Environmental Science and Engineering, Nankai 
      University, Tianjin, China.
FAU - Sun, Hongwen
AU  - Sun H
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China. Electronic address: sunhongwen@nankai.edu.cn.
FAU - Yao, Yiming
AU  - Yao Y
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Li, Yongcheng
AU  - Li Y
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Meng, Yue
AU  - Meng Y
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Lu, Yuan
AU  - Lu Y
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Han, Liping
AU  - Han L
AD  - Tianjin Medical University Metabolic Diseases Hospital, Tianjin, China.
FAU - Chen, Liming
AU  - Chen L
AD  - Tianjin Medical University Metabolic Diseases Hospital, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20210430
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
SB  - IM
MH  - *Alkanesulfonic Acids/toxicity
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/chemically induced/epidemiology
MH  - *Environmental Pollutants
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Odds Ratio
MH  - Sulfonic Acids
OTO - NOTNLM
OT  - Dose-response relationship
OT  - Low-dose effect
OT  - PFASs
OT  - PFHpA
OT  - PFHxS
OT  - T2DM risk
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/05/17 06:00
MHDA- 2021/06/16 06:00
CRDT- 2021/05/16 20:45
PHST- 2021/02/10 00:00 [received]
PHST- 2021/04/12 00:00 [revised]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/05/17 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2021/05/16 20:45 [entrez]
AID - S0048-9697(21)02547-X [pii]
AID - 10.1016/j.scitotenv.2021.147476 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Sep 15;787:147476. doi: 10.1016/j.scitotenv.2021.147476. 
      Epub 2021 Apr 30.