PMID- 33992987
OWN - NLM
STAT- MEDLINE
DCOM- 20210910
LR  - 20240402
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 31
DP  - 2021
TI  - Longitudinal [(18)F]FDG and [(13)N]NH(3) PET/CT imaging of brain and spinal cord 
      in a canine hemisection spinal cord injury model.
PG  - 102692
LID - S2213-1582(21)00136-4 [pii]
LID - 10.1016/j.nicl.2021.102692 [doi]
LID - 102692
AB  - To further understand the neurological changes induced by spinal cord injury 
      (SCI) in its acute and subacute stages, we evaluated longitudinal changes in 
      glucose and glutamate metabolism in the spinal cord and brain regions of a canine 
      hemisection SCI model. [(18)F]FDG and [(13)N]NH(3) positron-emission tomography 
      (PET) with computed tomography (CT) was performed before SCI and at 1, 3, 7, 14, 
      and 21 days after SCI. Spinal cord [(18)F]FDG uptake increased and peaked at 
      3 days post SCI. Similar changes were observed in the brain regions but were not 
      statistically significant. Compared to the acute phase of SCI, [(13)N]NH(3) 
      uptake increased in the subacute stage and peaked at 7 days post SCI in all 
      analyzed brain regions. But in spinal cord, no [(13)N]NH(3) uptake was detected 
      before SCI when the blood-spinal cord barrier (BSCB) was intact, then gradually 
      increased when the BSCB was damaged after SCI. [(13)N]NH(3) uptake was 
      significantly correlated with plasma levels of the BSCB disruption marker, 
      monocyte chemoattractant protein-1 (MCP-1). Overall, we showed that SCI induced 
      in vivo changes in glucose uptake in both the spinal cord and the examined brain 
      regions, and changes in glutamine synthetase activity in the latter. Moreover, 
      our results suggest that [(13)N]NH(3) PET may serve as a potential method for 
      assessing BSCB permeability in vivo.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Lijian
AU  - Zhang L
AD  - Department of Neurosurgery, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China; Department of Neurosurgery, Affiliated Hospital of 
      Hebei University, Baoding, Hebei, China.
FAU - Lopez-Picon, Francisco R
AU  - Lopez-Picon FR
AD  - Preclinical Imaging Laboratory, Turku PET Centre, University of Turku, Turku, 
      Finland; MediCity Research Laboratory, University of Turku, Turku, Finland.
FAU - Jia, Yingqin
AU  - Jia Y
AD  - Department of Nuclear Medicine, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China.
FAU - Chen, Yao
AU  - Chen Y
AD  - Department of Neurosurgery, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China.
FAU - Li, Juan
AU  - Li J
AD  - Department of Nuclear Medicine, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China.
FAU - Han, Chunlei
AU  - Han C
AD  - Clinical Imaging Laboratory, Turku PET Centre, University of Turku and Turku 
      University Hospital, Turku, Finland.
FAU - Zhuang, Xiaoqing
AU  - Zhuang X
AD  - Department of Nuclear Medicine, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China. Electronic address: zhuangxq@nyfy.com.cn.
FAU - Xia, Hechun
AU  - Xia H
AD  - Department of Neurosurgery, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China. Electronic address: xhechun@nyfy.com.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210504
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Brain/diagnostic imaging
MH  - Dogs
MH  - *Fluorodeoxyglucose F18
MH  - Positron Emission Tomography Computed Tomography
MH  - *Spinal Cord Injuries/diagnostic imaging
PMC - PMC8134064
OTO - NOTNLM
OT  - Blood spinal cord barrier (BSCB)
OT  - Canine
OT  - Glutamine synthetase
OT  - Longitudinal PET/CT imaging
OT  - Spinal cord injury
OT  - [(13)N]NH(3)
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/05/17 06:00
MHDA- 2021/09/11 06:00
PMCR- 2021/05/04
CRDT- 2021/05/16 20:48
PHST- 2021/01/16 00:00 [received]
PHST- 2021/04/21 00:00 [revised]
PHST- 2021/05/01 00:00 [accepted]
PHST- 2021/05/17 06:00 [pubmed]
PHST- 2021/09/11 06:00 [medline]
PHST- 2021/05/16 20:48 [entrez]
PHST- 2021/05/04 00:00 [pmc-release]
AID - S2213-1582(21)00136-4 [pii]
AID - 102692 [pii]
AID - 10.1016/j.nicl.2021.102692 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2021;31:102692. doi: 10.1016/j.nicl.2021.102692. Epub 2021 May 
      4.