PMID- 33993037
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 301
DP  - 2021 Jul
TI  - Smaller subcortical volumes and enlarged lateral ventricles are associated with 
      higher global functioning in young adults with 22q11.2 deletion syndrome with 
      prodromal symptoms of schizophrenia.
PG  - 113979
LID - S0165-1781(21)00276-6 [pii]
LID - 10.1016/j.psychres.2021.113979 [doi]
AB  - The 22q11.2 deletion syndrome (22q11DS) is a developmental genetic syndrome 
      associated with a 30% risk for developing schizophrenia. Lateral ventricles and 
      subcortical structures are abnormal in this syndrome as well as in schizophrenia. 
      Here, we investigated whether these structures are related in young adults with 
      22q11DS with and without prodromal symptoms (PS) for schizophrenia and whether 
      abnormalities in volumes are associated with global functioning. MR images were 
      acquired on a 3T scanner from 51 individuals with 22q11DS and 30 healthy controls 
      (mean age: 21+/-2 years). Correlations were performed to evaluate the relationship 
      between ventricular and subcortical volumes, with Global Assessment of 
      Functioning (GAF) and Premorbid Adjustment Scale (PAS) in each group. Lateral 
      ventricular volumes correlated negatively with subcortical volumes in individuals 
      with 22q11DS. In individuals with 22q11DS with PS only, GAF correlated positively 
      with volumes of the lateral ventricles and negatively with subcortical volumes. 
      PAS correlated negatively with lateral ventricle volumes, and positively with 
      volumes of subcortical structures. The results suggest a common 
      neurodevelopmental mechanism related to the growth of these brain structures. 
      Further, the ratio between the volumes and clinical measures could potentially be 
      used to characterize individuals with 22q11DS and those from the general 
      population for the risk of the development of schizophrenia.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Heller, Carina
AU  - Heller C
AD  - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, United States; Department of 
      Psychiatry and Psychotherapy, Jena University Hospital, Germany; Department of 
      Clinical Psychology, Friedrich-Schiller-University Jena, Am Steiger 3, Haus 1, 
      Jena 07743, Germany. Electronic address: carina.heller@uni-jena.de.
FAU - Weiss, Thomas
AU  - Weiss T
AD  - Department of Clinical Psychology, Friedrich-Schiller-University Jena, Am Steiger 
      3, Haus 1, Jena 07743, Germany.
FAU - Del Re, Elisabetta C
AU  - Del Re EC
AD  - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, United States; VA Boston Healthcare 
      System, Brockton, MA, United States.
FAU - Swago, Sophia
AU  - Swago S
AD  - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, United States.
FAU - Coman, Ioana L
AU  - Coman IL
AD  - Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical 
      University, Syracuse, NY, United States; Department of Computer Science, SUNY 
      Oswego, Oswego, NY, United States.
FAU - Antshel, Kevin M
AU  - Antshel KM
AD  - Department of Psychology, Syracuse University, Syracuse, NY, United States.
FAU - Fremont, Wanda
AU  - Fremont W
AD  - Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical 
      University, Syracuse, NY, United States.
FAU - Bouix, Sylvain
AU  - Bouix S
AD  - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, United States.
FAU - Kates, Wendy R
AU  - Kates WR
AD  - Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical 
      University, Syracuse, NY, United States.
FAU - Kubicki, Marek R
AU  - Kubicki MR
AD  - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, United States; Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 
      United States; Department of Psychiatry, Massachusetts General Hospital, Harvard 
      Medical School, Boston, MA, United States.
FAU - Kikinis, Zora
AU  - Kikinis Z
AD  - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210503
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - *DiGeorge Syndrome/complications/diagnostic imaging/genetics
MH  - Humans
MH  - Lateral Ventricles/diagnostic imaging
MH  - Prodromal Symptoms
MH  - *Psychotic Disorders/diagnostic imaging/genetics
MH  - *Schizophrenia/diagnostic imaging/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - 22q11.2 deletion syndrome
OT  - Global functioning
OT  - Lateral ventricles
OT  - Premorbid adjustment
OT  - Prodromal symptoms
OT  - Schizophrenia
OT  - Subcortical structures
EDAT- 2021/05/17 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/05/16 20:50
PHST- 2021/01/08 00:00 [received]
PHST- 2021/04/25 00:00 [accepted]
PHST- 2021/05/17 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
PHST- 2021/05/16 20:50 [entrez]
AID - S0165-1781(21)00276-6 [pii]
AID - 10.1016/j.psychres.2021.113979 [doi]
PST - ppublish
SO  - Psychiatry Res. 2021 Jul;301:113979. doi: 10.1016/j.psychres.2021.113979. Epub 
      2021 May 3.