PMID- 33993196
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20211221
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 56
IP  - 10
DP  - 2021 Oct
TI  - Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome 
      in adolescent and young adult patients.
PG  - 2510-2517
LID - 10.1038/s41409-021-01324-8 [doi]
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable 
      treatment option for adolescent and young adult (AYA) patients with 
      myelodysplastic syndrome (MDS). The study aim was to evaluate epidemiological 
      data and identify prognostic factors for AYA patients with MDS undergoing 
      allogeneic HSCT. Here, 645 patients were selected from patients enrolled in a 
      multicenter prospective registry for HSCT from 2000 to 2015. The primary endpoint 
      was 3-year overall survival (OS). Survival rates were estimated using the 
      Kaplan-Meier method. Prognostic factors were identified using the multivariable 
      Cox proportional hazards model. The 3-year OS was 71.2% (95% confidence interval 
      [CI]: 67.4-74.6%). In multivariable analysis, active disease status (adjusted 
      hazard ratio: 1.54, 95% CI: 1.09-2.18, p = 0.016), poor cytogenetic risk (1.62, 
      1.12-2.36, p = 0.011), poor performance status (2.01, 1.13-3.56, p = 0.016), 
      human leukocyte antigen (HLA)-matched unrelated donors (2.23, 1.39-3.59, 
      p < 0.001), HLA-mismatched unrelated donors (2.16, 1.09-4.28, p = 0.027), and 
      cord blood transplantation (2.44, 1.43-4.17, p = 0.001) were significantly 
      associated with poor 3-year OS. In conclusion, in AYA patients with MDS the 
      3-year OS following allogeneic HSCT was 71.2%. Active disease status, poor 
      cytogenetic risk, poor performance status, and donor sources other than related 
      donors were associated with poor 3-year OS.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Shimomura, Yoshimitsu
AU  - Shimomura Y
AUID- ORCID: 0000-0003-1018-9508
AD  - Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan. 
      shimomura_0119@yahoo.co.jp.
FAU - Hara, Masahiko
AU  - Hara M
AD  - Center for Community-Based Healthcare Research and Education, Shimane University, 
      Shimane, Japan.
FAU - Konuma, Takaaki
AU  - Konuma T
AUID- ORCID: 0000-0002-1496-376X
AD  - Department of Hematology/Oncology, The Institute of Medical Science, The 
      University of Tokyo, Tokyo, Japan.
FAU - Itonaga, Hidehiro
AU  - Itonaga H
AUID- ORCID: 0000-0003-1438-3623
AD  - Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
FAU - Doki, Noriko
AU  - Doki N
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital, Tokyo, Japan.
FAU - Ozawa, Yukiyasu
AU  - Ozawa Y
AD  - Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, 
      Japan.
FAU - Eto, Tetsuya
AU  - Eto T
AD  - Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
FAU - Uchida, Naoyuki
AU  - Uchida N
AUID- ORCID: 0000-0001-5952-5926
AD  - Department of Hematology, Toranomon Hospital, Tokyo, Japan.
FAU - Aoki, Jun
AU  - Aoki J
AUID- ORCID: 0000-0002-3412-0073
AD  - Department of Hematopoietic Stem Cell Transplantation, National Cancer Center 
      Hospital, Tokyo, Japan.
FAU - Kato, Jun
AU  - Kato J
AUID- ORCID: 0000-0003-1869-5480
AD  - Division of Hematology and department of Medicine, Keio University School of 
      Medicine, Tokyo, Japan.
FAU - Onishi, Yasushi
AU  - Onishi Y
AD  - Department of Hematology, Tohoku University Hospital, Miyagi, Japan.
FAU - Takahashi, Satoshi
AU  - Takahashi S
AD  - Division of Molecular Therapy, the Advanced Clinical Research Center, The 
      Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
FAU - Fukushima, Kentaro
AU  - Fukushima K
AD  - Department of Hematology and Oncology, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Nakamae, Hirohisa
AU  - Nakamae H
AUID- ORCID: 0000-0003-4203-990X
AD  - Department of Hematology, Graduate School of Medicine Osaka City University, 
      Osaka, Japan.
FAU - Kawakita, Toshiro
AU  - Kawakita T
AD  - Department of Hematology, National Hospital Organization Kumamoto Medical Center, 
      Kumamoto, Japan.
FAU - Tanaka, Junji
AU  - Tanaka J
AD  - Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Fukuda, Takahiro
AU  - Fukuda T
AD  - Department of Hematopoietic Stem Cell Transplantation, National Cancer Center 
      Hospital, Tokyo, Japan.
FAU - Atsuta, Yoshiko
AU  - Atsuta Y
AUID- ORCID: 0000-0003-4404-2870
AD  - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
AD  - Department of Healthcare Administration, Nagoya University Graduate School of 
      Medicine, Nagoya, Japan.
FAU - Ishikawa, Takayuki
AU  - Ishikawa T
AD  - Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.
FAU - Ishiyama, Ken
AU  - Ishiyama K
AUID- ORCID: 0000-0002-6189-0620
AD  - Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210515
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adolescent
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Myelodysplastic Syndromes/therapy
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Tissue Donors
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2021/05/17 06:00
MHDA- 2021/10/14 06:00
CRDT- 2021/05/16 20:56
PHST- 2020/12/14 00:00 [received]
PHST- 2021/04/21 00:00 [accepted]
PHST- 2021/04/14 00:00 [revised]
PHST- 2021/05/17 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/05/16 20:56 [entrez]
AID - 10.1038/s41409-021-01324-8 [pii]
AID - 10.1038/s41409-021-01324-8 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2021 Oct;56(10):2510-2517. doi: 
      10.1038/s41409-021-01324-8. Epub 2021 May 15.