PMID- 33993859
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20211204
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 86
IP  - 5
DP  - 2021 May
TI  - Protein Phosphorylation Signaling Cascades in Autism: The Role of mTOR Pathway.
PG  - 577-596
LID - 10.1134/S0006297921050072 [doi]
AB  - The mammalian target of rapamycin (mTOR) signaling pathway is a central regulator 
      of cell metabolism, growth, and survival in response to hormones, growth factors, 
      nutrients, and stress-induced signals. In this review, we analyzed the studies on 
      the molecular abnormalities of the mTOR-associated signaling cascades in autism 
      spectrum disorders (ASDs) and outlined the prospects for the 
      pathogenicity-targeting pharmacotherapeutic approaches to ASDs, in particular 
      syndromic ASDs. Based on available experimental and clinical data, we suggest 
      that very early detection of molecular abnormalities in the ASD risk groups can 
      be facilitated by using peripheral blood platelets. Also, identification of the 
      time window of critical dysregulations in the described pathways in the ASD risk 
      groups might suggest further research directions leading to more efficacious 
      pharmacotherapeutic interventions in ASDs.
FAU - Boksha, Irina S
AU  - Boksha IS
AD  - Mental Health Research Center, Moscow, 115522, Russia. boksha_irina@mail.ru.
AD  - Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Health of 
      the Russian Federation, Moscow, 123098, Russia.
FAU - Prokhorova, Tatyana A
AU  - Prokhorova TA
AD  - Mental Health Research Center, Moscow, 115522, Russia.
FAU - Tereshkina, Elena B
AU  - Tereshkina EB
AD  - Mental Health Research Center, Moscow, 115522, Russia.
FAU - Savushkina, Olga K
AU  - Savushkina OK
AD  - Mental Health Research Center, Moscow, 115522, Russia.
FAU - Burbaeva, Gulnur Sh
AU  - Burbaeva GS
AD  - Mental Health Research Center, Moscow, 115522, Russia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Autism Spectrum Disorder/metabolism
MH  - Autistic Disorder/*metabolism
MH  - Humans
MH  - Phosphorylation
MH  - Protein Processing, Post-Translational
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - autism spectrum disorders
OT  - mTOR
OT  - protein phosphorylation
OT  - signaling cascades
EDAT- 2021/05/18 06:00
MHDA- 2021/07/10 06:00
CRDT- 2021/05/17 05:32
PHST- 2021/05/17 05:32 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
AID - BCM86050643 [pii]
AID - 10.1134/S0006297921050072 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2021 May;86(5):577-596. doi: 10.1134/S0006297921050072.