PMID- 33994447
OWN - NLM
STAT- MEDLINE
DCOM- 20210518
LR  - 20231111
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 60
IP  - 10
DP  - 2021
TI  - Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome.
PG  - 1601-1605
LID - 10.2169/internalmedicine.6468-20 [doi]
AB  - Cronkhite-Canada syndrome (CCS) is a rare polyposis disorder accompanied by 
      alopecia and onychodystrophy. A 63-year-old man with a history of CCS and 
      repeated embolism developed progressive thrombocytopenia and mild anemia. 
      Laboratory testing, a bone marrow examination, and magnetic resonance imaging of 
      the spine resulted in a diagnosis of concurrent aplastic anemia (AA). Paroxysmal 
      nocturnal hemoglobinuria (PNH)-type cells were detected in a peripheral blood 
      specimen. In addition, human leukocyte antigen (HLA) included DRB1*15:01 and 
      DRB1*15:02. Mesalazine was discontinued in consideration of possible drug-induced 
      pancytopenia. Immunosuppressive therapy ameliorated both the gastrointestinal 
      symptoms of CCS and pancytopenia. A common autoimmune abnormality might underlie 
      both CCS and AA.
FAU - Kidoguchi, Keisuke
AU  - Kidoguchi K
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
FAU - Kubota, Yasushi
AU  - Kubota Y
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
AD  - Department of Transfusion Medicine, Saga University Hospital, Japan.
FAU - Fujimoto, Shun
AU  - Fujimoto S
AD  - Division of Gastroenterology, Department of Internal Medicine, Faculty of 
      Medicine, Saga University, Japan.
FAU - Sakata, Yasuhisa
AU  - Sakata Y
AD  - Division of Gastroenterology, Department of Internal Medicine, Faculty of 
      Medicine, Saga University, Japan.
FAU - Kizuka-Sano, Haruna
AU  - Kizuka-Sano H
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
FAU - Yamaguchi, Kyosuke
AU  - Yamaguchi K
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
FAU - Ureshino, Hiroshi
AU  - Ureshino H
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
FAU - Katsuya, Hiroo
AU  - Katsuya H
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
FAU - Ando, Toshihiko
AU  - Ando T
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
FAU - Esaki, Motohiro
AU  - Esaki M
AD  - Division of Gastroenterology, Department of Internal Medicine, Faculty of 
      Medicine, Saga University, Japan.
FAU - Kimura, Shinya
AU  - Kimura S
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210515
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 4Q81I59GXC (Mesalamine)
SB  - IM
MH  - *Anemia, Aplastic/complications/diagnosis
MH  - *Hemoglobinuria, Paroxysmal/complications/diagnosis
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - *Intestinal Polyposis/complications/diagnosis
MH  - Male
MH  - Mesalamine
MH  - Middle Aged
PMC - PMC8188031
OTO - NOTNLM
OT  - Cronkhite-Canada syndrome
OT  - aplastic anemia
OT  - autoimmune disorder
OT  - human leukocyte antigen
OT  - paroxysmal nocturnal hemoglobinuria
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2021/05/18 06:00
MHDA- 2021/05/19 06:00
PMCR- 2021/05/15
CRDT- 2021/05/17 05:52
PHST- 2021/05/17 05:52 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/19 06:00 [medline]
PHST- 2021/05/15 00:00 [pmc-release]
AID - 10.2169/internalmedicine.6468-20 [doi]
PST - ppublish
SO  - Intern Med. 2021;60(10):1601-1605. doi: 10.2169/internalmedicine.6468-20. Epub 
      2021 May 15.