PMID- 33995358
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20240402
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 12
DP  - 2021
TI  - High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and 
      Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han.
PG  - 640334
LID - 10.3389/fimmu.2021.640334 [doi]
LID - 640334
AB  - Killer cell immunoglobulin-like receptors (KIR) interact with human leukocyte 
      antigen (HLA) class I molecules, modulating critical NK cell functions in the 
      maintenance of human health. Characterizing the distribution and characteristics 
      of KIR and HLA allotype diversity across defined human populations is thus 
      essential for understanding the multiple associations with disease, and for 
      directing therapies. In this study of 176 Zhejiang Han individuals from 
      Southeastern China, we describe diversity of the highly polymorphic KIR and HLA 
      class I genes at high resolution. KIR-A haplotypes, which carry four inhibitory 
      receptors specific for HLA-A, B or C, are known to associate with protection from 
      infection and some cancers. We show the Chinese Southern Han from Zhejiang are 
      characterized by a high frequency of KIR-A haplotypes and a high frequency of C1 
      KIR ligands. Accordingly, interactions of inhibitory KIR2DL3 with C1(+)HLA are 
      more frequent in Zhejiang Han than populations outside East Asia. Zhejiang Han 
      exhibit greater diversity of inhibitory than activating KIR, with three-domain 
      inhibitory KIR exhibiting the greatest degree of polymorphism. As distinguished 
      by gene copy number and allele content, 54 centromeric and 37 telomeric 
      haplotypes were observed. We observed 6% of the population to have KIR haplotypes 
      containing large-scale duplications or deletions that include complete genes. A 
      unique truncated haplotype containing only KIR2DL4 in the telomeric region was 
      also identified. An additional feature is the high frequency of HLA-B*46:01, 
      which may have arisen due to selection pressure from infectious disease. This 
      study will provide further insight into the role of KIR and HLA polymorphism in 
      disease susceptibility of Zhejiang Chinese.
CI  - Copyright (c) 2021 Tao, He, Kichula, Wang, He, Norman and Zhu.
FAU - Tao, Sudan
AU  - Tao S
AD  - Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of 
      Zhejiang Province, Hangzhou, China.
FAU - He, Yanmin
AU  - He Y
AD  - Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of 
      Zhejiang Province, Hangzhou, China.
FAU - Kichula, Katherine M
AU  - Kichula KM
AD  - Division of Biomedical Informatics and Personalized Medicine, and Department of 
      Immunology and Microbiology, University of Colorado Anschutz Medical Campus, 
      Aurora, CO, United States.
FAU - Wang, Jielin
AU  - Wang J
AD  - Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of 
      Zhejiang Province, Hangzhou, China.
FAU - He, Ji
AU  - He J
AD  - Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of 
      Zhejiang Province, Hangzhou, China.
FAU - Norman, Paul J
AU  - Norman PJ
AD  - Division of Biomedical Informatics and Personalized Medicine, and Department of 
      Immunology and Microbiology, University of Colorado Anschutz Medical Campus, 
      Aurora, CO, United States.
FAU - Zhu, Faming
AU  - Zhu F
AD  - Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of 
      Zhejiang Province, Hangzhou, China.
LA  - eng
GR  - R01 AI128775/AI/NIAID NIH HHS/United States
GR  - R56 AI151549/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210430
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Asian People/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Lymphocyte Activation/immunology
MH  - Receptors, KIR/*genetics
PMC - PMC8121542
OTO - NOTNLM
OT  - HLA
OT  - KIR
OT  - KIR/HLA interaction
OT  - NK cells
OT  - Zhejiang Han population
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/18 06:00
MHDA- 2021/09/21 06:00
PMCR- 2021/01/01
CRDT- 2021/05/17 06:04
PHST- 2020/12/11 00:00 [received]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/05/17 06:04 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2021.640334 [doi]
PST - epublish
SO  - Front Immunol. 2021 Apr 30;12:640334. doi: 10.3389/fimmu.2021.640334. eCollection 
      2021.