PMID- 33995958
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2008-4633 (Print)
IS  - 2008-8469 (Electronic)
IS  - 2008-4633 (Linking)
VI  - 13
IP  - 1
DP  - 2021 Jan
TI  - The Effects of Folic Acid on Testicular Histology, Sperm Quality, and 
      Spermatogenesis Indices Following 3,4-Methylenedioxymethamphetamine Exposure in 
      Adult Male Rats.
PG  - 36-44
LID - 10.22122/ahj.v13i1.295 [doi]
AB  - BACKGROUND: There is an increasing concern over acute exposure of amphetamine and 
      its derivative such as 3,4-methylenedioxymethamphetamine (MDMA) on male 
      reproductive toxicity. Supplementary vitamins can reduce the oxidative stresses 
      and repair the damages on reproductive organs. This experimental study was 
      conducted to evaluate the effects of folic acid (FA) on reproductive indices, the 
      antioxidant enzyme activities, and histological changes of testis on adult male 
      rats treated by MDMA. METHODS: This experimental study was conducted on adult 
      male Wistar rats. Animals were divided into 4 groups: control, MDMA, FA, and MDMA 
      + FA. Animals received a dose of 10 mg/kg of MDMA and 1 mg/kg of FA for 7 or 14 
      days. Rats were anesthetized and sperm quality parameters (number, concentration, 
      motility, and morphology), spermatogenesis indices [the mean seminiferous tubule 
      diameter (MSTD), spermiogenesis index (SI), repopulation index (RI), and tubular 
      differentiation index (TDI)], changes on testicular structure, antioxidant enzyme 
      activities of catalase (CAT), superoxide dismutase (SOD), and malondialdehyde 
      (MDA) beside serum level of luteinizing hormone (LH), follicle-stimulating 
      hormone (FSH), and testosterone were measured. Data were analyzed, using the 
      one-way analysis of variance (ANOVA) and SPSS software. FINDINGS: MDMA (both 7 
      and 14 days) caused significant changes in sperm quality (P < 0.001), 
      spermatogenesis indices (P < 0.001), testicular histopathology, and level of LH, 
      FSH, testosterone beside the antioxidant enzyme activities (SOD, CAT, and MDA) (P 
      < 0.001). Supplementation of FA in association with MDMA partially reversed these 
      parameters and made them close to the control group. CONCLUSION: The results 
      suggested that FA could reduce the adverse effect of MDMA on reproductive ability 
      in adult male rats.
CI  - (c) 2020 Kerman University of Medical Sciences.
FAU - Rad, Iman
AU  - Rad I
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
FAU - Saberi, Arezoo
AU  - Saberi A
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
FAU - Koochakzadeh-Nematollahi, Najmeh Sadat
AU  - Koochakzadeh-Nematollahi NS
AD  - Afzalipour Clinical Center for Infertility, Afzalipour Hospital, Kerman 
      University of Medical Sciences, Kerman, Iran.
FAU - Habibzadeh, Victoria
AU  - Habibzadeh V
AD  - Afzalipour Clinical Center for Infertility, Afzalipour Hospital, Kerman 
      University of Medical Sciences, Kerman, Iran.
FAU - Salarkia, Ehsan
AU  - Salarkia E
AD  - Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, 
      Iran.
FAU - Amanollahi, Sedigheh
AU  - Amanollahi S
AD  - Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, 
      Iran.
FAU - Nikpour, Saeideh
AU  - Nikpour S
AD  - Department of Parasitology and Mycology, School of Medicine, Iran University of 
      Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Addict Health
JT  - Addiction & health
JID - 101582275
PMC - PMC8080174
OTO - NOTNLM
OT  - Folic acid
OT  - N-Methyl-3,4-methylenedioxyamphetamine
OT  - Rats
OT  - Spermatogenesis
OT  - Spermatozoa
EDAT- 2021/05/18 06:00
MHDA- 2021/05/18 06:01
PMCR- 2021/01/01
CRDT- 2021/05/17 06:08
PHST- 2021/05/17 06:08 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/18 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - AHJ-13-036 [pii]
AID - 10.22122/ahj.v13i1.295 [doi]
PST - ppublish
SO  - Addict Health. 2021 Jan;13(1):36-44. doi: 10.22122/ahj.v13i1.295.