PMID- 33996105
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2054-2704 (Print)
IS  - 2054-2704 (Electronic)
IS  - 2054-2704 (Linking)
VI  - 12
IP  - 4
DP  - 2021 Apr
TI  - The first reported cases of meat allergy following tick bites in the UK.
PG  - 2054270421996131
LID - 10.1177/2054270421996131 [doi]
LID - 2054270421996131
AB  - Allergic reactions frequently involve the production of immunoglobulin E (IgE) 
      antibodies to proteins. However, reactions directed against carbohydrate moieties 
      are increasingly being recognised. Tick bites can contribute to the development 
      of immunoglobulin E to the galactose-1,3-galactose (alpha-gal) moiety on tick 
      salivary proteins. These IgE molecules can cross-react with alpha-gal found in 
      red meats, causing Type I IgE-mediated hypersensitivity reactions to these foods. 
      We present three cases of delayed reactions to beef, pork and lamb in patients 
      with prior tick bites and in the presence of a positive-specific IgE to 
      alpha-gal. Patients were advised to avoid red meat consumption and to carry 
      emergency treatment in the form of anti-histamines with or without adrenaline 
      autoinjector devices. This is the first published report of red meat allergy 
      caused by tick bites suffered in the UK.
CI  - (c) The Author(s) 2021.
FAU - Bansal, Rhea A
AU  - Bansal RA
AUID- ORCID: 0000-0002-8049-982X
AD  - Immunology Department, Frimley Park Hospital, Frimley Health NHS Trust, Frimley 
      GU16 7UJ, UK.
FAU - Bahal, Sameer
AU  - Bahal S
AD  - Immunology Department, The Royal Free Hospital, Royal Free London NHS Foundation 
      Trust, London NW3 2QG, UK. RINGGOLD: 4965
FAU - O'Brien, Rachael
AU  - O'Brien R
AD  - Immunology Department, Frimley Park Hospital, Frimley Health NHS Trust, Frimley 
      GU16 7UJ, UK.
FAU - Miller, Joanne
AU  - Miller J
AD  - Immunology Department, Royal Surrey County Hospital, Royal Surrey NHS Foundation 
      Trust, Surrey GU2 7XX, UK. RINGGOLD: 3661
FAU - Bansal, Amolak S
AU  - Bansal AS
AD  - St Anthony's Hospital, Cheam, SM3 9DW, UK.
FAU - Yong, Patrick Fk
AU  - Yong PF
AUID- ORCID: 0000-0003-1736-2756
AD  - Immunology Department, Frimley Park Hospital, Frimley Health NHS Trust, Frimley 
      GU16 7UJ, UK.
AD  - Immunology Department, Royal Surrey County Hospital, Royal Surrey NHS Foundation 
      Trust, Surrey GU2 7XX, UK. RINGGOLD: 3661
LA  - eng
PT  - Case Reports
DEP - 20210428
PL  - England
TA  - JRSM Open
JT  - JRSM open
JID - 101625786
PMC - PMC8107943
OTO - NOTNLM
OT  - Clinical
OT  - immunology (including allergy)
OT  - other pathology
OT  - pathology
EDAT- 2021/05/18 06:00
MHDA- 2021/05/18 06:01
PMCR- 2021/04/28
CRDT- 2021/05/17 06:10
PHST- 2021/05/17 06:10 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/18 06:01 [medline]
PHST- 2021/04/28 00:00 [pmc-release]
AID - 10.1177_2054270421996131 [pii]
AID - 10.1177/2054270421996131 [doi]
PST - epublish
SO  - JRSM Open. 2021 Apr 28;12(4):2054270421996131. doi: 10.1177/2054270421996131. 
      eCollection 2021 Apr.