PMID- 33996155
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2090-214X (Print)
IS  - 2090-2158 (Electronic)
VI  - 2021
DP  - 2021
TI  - Diagnostic Accuracy of Serum Cystatin C for Early Recognition of Nephropathy in 
      Type 2 Diabetes Mellitus.
PG  - 8884126
LID - 10.1155/2021/8884126 [doi]
LID - 8884126
AB  - OBJECTIVES: Diabetic nephropathy is one of the major complications that develop 
      over time in type 2 diabetes mellitus (T2DM). This prospective study was 
      conducted to assess the diagnostic accuracy of serum cystatin C in detecting 
      diabetic nephropathy at earlier stages. MATERIALS AND METHODS: This study was 
      undertaken on 50 cases of T2DM and 50 healthy subjects as controls. Demographic 
      and anthropometric data and blood and urine samples were collected. The 
      concentration of serum cystatin C (index test) and traditional markers of 
      diabetic nephropathy, serum creatinine, and urinary microalbumin (the reference 
      standard) were estimated. Similarly, blood glucose, glycated haemoglobin (HbA1c), 
      triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, and 
      urinary creatine were measured. RESULTS: The mean +/- SD serum cystatin C was 
      significantly higher in T2DM as compared to control (1.07 +/- 0.38 and 
      0.86 +/- 0.12 mg/dl, respectively, p < 0.001). The mean +/- SD bodyweight, BMI, W : H 
      ratio, pulse, SBP, and DBP were 66.4 +/- 12.6 kg, 26.2 +/- 5.6 kg/m(2), 1.03 +/- 0.09, 
      78 +/- 7, 125 +/- 16 mm of Hg, and 77 +/- 9 mm of Hg, respectively, in cases. A 
      significant difference in HDL cholesterol (p=0.018) and serum cystatin C (p < 
      0.001) was observed among different grades of nephropathy. Cystatin C had a 
      significant positive correlation with age (r = 0.323, p=0.022), duration of T2DM 
      (r = 0.326, p=0.021), and UACR (r = 0.528, p < 0.001) and a significant negative 
      correlation with eGFR CKD-EPI cystatin C (r = -0.925, p < 0.001). The area under 
      ROC curve for serum cystatin C (0.611, 95% CI: 0.450-0.772) was greater than for 
      serum creatinine (0.429, 95% CI: 0.265-0.593) though nonsignificant. CONCLUSION: 
      Serum cystatin C concentration increases with the progression of nephropathy and 
      duration of diabetes in Nepalese T2DM patients suggesting cystatin C as a 
      potential marker of renal impairment in T2DM patients.
CI  - Copyright (c) 2021 Suman Sapkota et al.
FAU - Sapkota, Suman
AU  - Sapkota S
AD  - Lumbini Zonal Hospital, Butwal, Nepal.
FAU - Khatiwada, Saroj
AU  - Khatiwada S
AUID- ORCID: 0000-0002-5158-9324
AD  - School of Medical Sciences, UNSW Sydney, Kensington, Australia.
FAU - Shrestha, Shrijana
AU  - Shrestha S
AD  - Department of Biochemistry, B P Koirala Institute of Health Sciences, Ghopa, 
      Dharan, Nepal.
FAU - Baral, Nirmal
AU  - Baral N
AD  - Department of Biochemistry, B P Koirala Institute of Health Sciences, Ghopa, 
      Dharan, Nepal.
FAU - Maskey, Robin
AU  - Maskey R
AUID- ORCID: 0000-0001-8272-5141
AD  - Department of Internal Medicine, B P Koirala Institute of Health Sciences, 
      Dharan, Nepal.
FAU - Majhi, Shankar
AU  - Majhi S
AD  - Department of Biochemistry, B P Koirala Institute of Health Sciences, Ghopa, 
      Dharan, Nepal.
FAU - Chandra, Lal
AU  - Chandra L
AD  - Department of Biochemistry, Maulana Azad Medical College, New Delhi, India.
FAU - Lamsal, Madhab
AU  - Lamsal M
AUID- ORCID: 0000-0003-2619-7414
AD  - Department of Biochemistry, B P Koirala Institute of Health Sciences, Ghopa, 
      Dharan, Nepal.
LA  - eng
PT  - Journal Article
DEP - 20210426
PL  - United States
TA  - Int J Nephrol
JT  - International journal of nephrology
JID - 101546753
PMC - PMC8096588
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/05/18 06:00
MHDA- 2021/05/18 06:01
PMCR- 2021/04/26
CRDT- 2021/05/17 06:11
PHST- 2020/09/05 00:00 [received]
PHST- 2021/02/23 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/05/17 06:11 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/18 06:01 [medline]
PHST- 2021/04/26 00:00 [pmc-release]
AID - 10.1155/2021/8884126 [doi]
PST - epublish
SO  - Int J Nephrol. 2021 Apr 26;2021:8884126. doi: 10.1155/2021/8884126. eCollection 
      2021.