PMID- 33996170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 21
IP  - 2
DP  - 2021 Apr
TI  - Intranasal Vaccination with Outer-Membrane Protein of Orientia tsutsugamushi 
      induces Protective Immunity Against Scrub Typhus.
PG  - e14
LID - 10.4110/in.2021.21.e14 [doi]
LID - e14
AB  - Scrub typhus develops after the individual is bitten by a trombiculid mite 
      infected with Orientia tsutsugamushi. Since it has been reported that pneumonia 
      is frequently observed in patients with scrub typhus, we investigated whether 
      intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi 
      (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It 
      was particular interest that when mice were infected with O. tsutsugamushi, the 
      bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination 
      with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. 
      The anti-O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a 
      high correlation of the protection against O. tsutsugamushi. The vaccination 
      induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. 
      In conclusion, the current study demonstrated that i.n. vaccination with OMPOT 
      elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi 
      infection causing subsequent pneumonia.
CI  - Copyright (c) 2021. The Korean Association of Immunologists.
FAU - Park, Sung-Moo
AU  - Park SM
AUID- ORCID: 0000-0002-7505-1617
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
FAU - Gu, Min Jeong
AU  - Gu MJ
AUID- ORCID: 0000-0001-8461-3776
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
FAU - Ju, Young-Jun
AU  - Ju YJ
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
FAU - Cheon, In Su
AU  - Cheon IS
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
AD  - Laboratory Sciences Division, International Vaccine Institute, Seoul 08826, 
      Korea.
FAU - Hwang, Kyu-Jam
AU  - Hwang KJ
AUID- ORCID: 0000-0001-9499-8059
AD  - Division of Zoonotic and Vector Borne Disease Research, Center for Infectious 
      Disease Research, National Institute of Health, Cheongju 28159, Korea .
FAU - Gill, Byoungchul
AU  - Gill B
AUID- ORCID: 0000-0002-3330-4196
AD  - Division of Zoonotic and Vector Borne Disease Research, Center for Infectious 
      Disease Research, National Institute of Health, Cheongju 28159, Korea .
FAU - Shim, Byoung-Shik
AU  - Shim BS
AD  - Laboratory Sciences Division, International Vaccine Institute, Seoul 08826, 
      Korea.
FAU - Jeong, Hang-Jin
AU  - Jeong HJ
AUID- ORCID: 0000-0003-0475-0231
AD  - Division of Zoonotic and Vector Borne Disease Research, Center for Infectious 
      Disease Research, National Institute of Health, Cheongju 28159, Korea .
FAU - Son, Young Min
AU  - Son YM
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
FAU - Choi, Sangho
AU  - Choi S
AUID- ORCID: 0000-0003-0452-4170
AD  - Division of Zoonotic and Vector Borne Disease Research, Center for Infectious 
      Disease Research, National Institute of Health, Cheongju 28159, Korea .
FAU - Jeung, Woonhee
AU  - Jeung W
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
FAU - Han, Seung Hyun
AU  - Han SH
AD  - Department of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, 
      School of Dentistry, Seoul National University, Seoul 08826, Korea.
FAU - Chu, Hyuk
AU  - Chu H
AUID- ORCID: 0000-0002-7044-2942
AD  - Division of Zoonotic and Vector Borne Disease Research, Center for Infectious 
      Disease Research, National Institute of Health, Cheongju 28159, Korea .
FAU - Yun, Cheol-Heui
AU  - Yun CH
AUID- ORCID: 0000-0002-0041-2887
AD  - Department of Agricultural Biotechnology and Research Institute of Agriculture 
      and Life Sciences, Seoul National University, Seoul 08826, Korea.
AD  - Institutes of Green Bio Science and Technology, Seoul National University, 
      Pyeongchang 25354, Korea.
AD  - Interdisciplinary Program in Agricultural Genomics, Seoul National University, 
      Seoul 08826, Korea.
LA  - eng
PT  - Journal Article
DEP - 20201203
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC8099613
OTO - NOTNLM
OT  - Intranasal administration
OT  - Orientia tsutsugamushi
OT  - Pneumonia
OT  - Protective immunity
COIS- Conflict of Interest: The authors declare no potential conflicts of interest.
EDAT- 2021/05/18 06:00
MHDA- 2021/05/18 06:01
PMCR- 2021/04/01
CRDT- 2021/05/17 06:11
PHST- 2020/03/16 00:00 [received]
PHST- 2020/10/12 00:00 [revised]
PHST- 2020/11/02 00:00 [accepted]
PHST- 2021/05/17 06:11 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/18 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - 10.4110/in.2021.21.e14 [doi]
PST - epublish
SO  - Immune Netw. 2020 Dec 3;21(2):e14. doi: 10.4110/in.2021.21.e14. eCollection 2021 
      Apr.