PMID- 33996504
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2214-7500 (Electronic)
IS  - 2214-7500 (Linking)
VI  - 8
DP  - 2021
TI  - The cardio and renoprotective role of ginseng against epinephrine-induced 
      myocardial infarction in rats: Involvement of angiotensin II type 1 
      receptor/protein kinase C.
PG  - 908-919
LID - 10.1016/j.toxrep.2021.04.008 [doi]
AB  - The expression of angiotensin II type 1 receptor (AT1 receptor)/protein kinase C 
      (PKC) in heart tissues has a vital role in myocardial infarction (MI). The 
      current work aimed to clarify the renal complication enhanced by MI following 
      epinephrine injection via AT1 receptor/ PKC expression; in addition, the impact 
      of ginseng extract on epinephrine-induced MI and its renal complication was 
      assessed. Adult male albino Wistar rats were pretreated orally with ginseng 
      extract (200 & 400 mg/kg/day) for 14 days, then two successive doses of 
      epinephrine injection (100 mg/kg, i.p.). Epinephrine evoked electrocardiographic 
      (ECG) and renal changes accompanied with a significant increase in heart and 
      kidney contents of malodialdehyde (MDA), nitric oxide (NO), protein kinase C 
      (PKC), heart contents of nuclear factor-kabba B (NF-kappaB) and angiotensin 1receptor 
      (AT1R), as well as a decrease in heart and kidney reduced glutathione (GSH) and 
      nuclear factor-erythroid-related factor 2 (Nrf2) contents. In histopathological 
      investigations epinephrine exhibited deleterious heart changes in the form of 
      acute MI with the presence of necrosis of cardiomyocytes with iNOS expression and 
      produced glomerulus and renal tubules degeneration. Pretreatment of rats with 
      ginseng extract in both doses significantly corrected epinephrine-induced heart 
      and renal changes. The current work revealed that epinephrine-induced MI 
      associated with aggravated renal complication and ginseng extract has cardio and 
      reno protective role against this as it reduces infarct size, preserves cardiac 
      and renal tissues and functions through activating Nrf2 and down-regulating 
      NF-kappaB, PKC, AT1R and iNOS.
CI  - (c) 2021 Published by Elsevier B.V.
FAU - Salama, Abeer
AU  - Salama A
AD  - Pharmacology Department, Medical Division, National Research Centre, 33 El 
      Bohouth St. (Former El-Tahrir St.), 12622 Dokki, Cairo, Egypt.
FAU - Mansour, Dina
AU  - Mansour D
AD  - Pharmacology Department, Medical Division, National Research Centre, 33 El 
      Bohouth St. (Former El-Tahrir St.), 12622 Dokki, Cairo, Egypt.
FAU - Hegazy, Rehab
AU  - Hegazy R
AD  - Pharmacology Department, Medical Division, National Research Centre, 33 El 
      Bohouth St. (Former El-Tahrir St.), 12622 Dokki, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20210420
PL  - Ireland
TA  - Toxicol Rep
JT  - Toxicology reports
JID - 101630272
PMC - PMC8099916
OTO - NOTNLM
OT  - AT1R
OT  - Ginseng
OT  - Myocardial infarction
OT  - Nrf2
OT  - PKC
COIS- The authors report no declarations of interest.
EDAT- 2021/05/18 06:00
MHDA- 2021/05/18 06:01
PMCR- 2021/04/20
CRDT- 2021/05/17 06:15
PHST- 2020/01/11 00:00 [received]
PHST- 2021/02/26 00:00 [revised]
PHST- 2021/04/16 00:00 [accepted]
PHST- 2021/05/17 06:15 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/18 06:01 [medline]
PHST- 2021/04/20 00:00 [pmc-release]
AID - S2214-7500(21)00084-6 [pii]
AID - 10.1016/j.toxrep.2021.04.008 [doi]
PST - epublish
SO  - Toxicol Rep. 2021 Apr 20;8:908-919. doi: 10.1016/j.toxrep.2021.04.008. 
      eCollection 2021.