PMID- 33996794
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210930
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 9
DP  - 2021
TI  - The Earliest T-Precursors in the Mouse Embryo Are Susceptible to Leukemic 
      Transformation.
PG  - 634151
LID - 10.3389/fcell.2021.634151 [doi]
LID - 634151
AB  - Acute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric 
      patients. About 10-15% of pediatric ALL belong to T-cell ALL (T-ALL), which is 
      characterized by aggressive expansion of immature T-lymphoblasts and is 
      categorized as high-risk leukemia. Leukemia initiating cells represent a 
      reservoir that is responsible for the initiation and propagation of leukemia. Its 
      perinatal origin has been suggested in some childhood acute B-lymphoblastic and 
      myeloblastic leukemias. Therefore, we hypothesized that child T-ALL initiating 
      cells also exist during the perinatal period. In this study, T-ALL potential of 
      the hematopoietic precursors was found in the para-aortic splanchnopleura (P-Sp) 
      region, but not in the extraembryonic yolk sac (YS) of the mouse embryo at 
      embryonic day 9.5. We overexpressed the Notch intracellular domain (NICD) in the 
      P-Sp and YS cells and transplanted them into lethally irradiated mice. 
      NICD-overexpressing P-Sp cells rapidly developed T-ALL while YS cells failed to 
      display leukemia propagation despite successful NICD induction. These results 
      suggest a possible role of fetal-derived T-cell precursors as leukemia-initiating 
      cells.
CI  - Copyright (c) 2021 Ding, Cardoso, Yoshimoto and Kobayashi.
FAU - Ding, Jixin
AU  - Ding J
AD  - Department of Medicine, Melvin and Bren Simon Cancer Center, Indiana University 
      School of Medicine, Indianapolis, IN, United States.
FAU - Cardoso, Angelo A
AU  - Cardoso AA
AD  - Department of Medicine, Melvin and Bren Simon Cancer Center, Indiana University 
      School of Medicine, Indianapolis, IN, United States.
AD  - Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, 
      United States.
FAU - Yoshimoto, Momoko
AU  - Yoshimoto M
AD  - Department of Pediatrics Wells Center for Pediatric Research, Indiana University 
      School of Medicine, Indianapolis, IN, United States.
AD  - Center for Stem Cell and Regenerative Medicine, Institute of Molecular Medicine, 
      McGovern Medical School, University of Texas Health Science Center at Houston, 
      Houston, TX, United States.
FAU - Kobayashi, Michihiro
AU  - Kobayashi M
AD  - Department of Pediatrics Wells Center for Pediatric Research, Indiana University 
      School of Medicine, Indianapolis, IN, United States.
AD  - Center for Stem Cell and Regenerative Medicine, Institute of Molecular Medicine, 
      McGovern Medical School, University of Texas Health Science Center at Houston, 
      Houston, TX, United States.
LA  - eng
GR  - R01 AI121197/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20210429
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8117020
OTO - NOTNLM
OT  - acute T cell leukemia
OT  - aorta-gonad-mesonephros region
OT  - hematopoietic stem cell-independent hematopoiesis
OT  - notch intracellular domain
OT  - notch signaling
OT  - para-aortic splanchnopleura
OT  - yolk sac
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/18 06:00
MHDA- 2021/05/18 06:01
PMCR- 2021/01/01
CRDT- 2021/05/17 06:16
PHST- 2020/11/27 00:00 [received]
PHST- 2021/04/06 00:00 [accepted]
PHST- 2021/05/17 06:16 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/18 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2021.634151 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2021 Apr 29;9:634151. doi: 10.3389/fcell.2021.634151. 
      eCollection 2021.